Results 11 to 20 of about 15,144 (118)

Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer [PDF]

The Korean Journal of Internal Medicine, 2021
Background/Aims Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Chang Hyun Nam, Jaemoon Koh, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo   +9 more
doaj   +1 more source

Human Rhinovirus Infection Enhances the Th2 Environment in Allergic and Non-allergic Patients with Chronic Rhinosinusitis [PDF]

Clinical and Experimental Otorhinolaryngology, 2021
Objectives. This study was conducted to determine whether patients with allergic rhinitis might be more susceptible to human rhinovirus (HRV) infection and whether the effects of infection on the elicited immune responses are different in allergic and ...
Young-Kyung Ko, Yu-Lian Zhang, Jee Hye Wee, Doo Hee Han, Hyun Jik Kim, Chae-Seo Rhee   +5 more
doaj   +1 more source

EFFECT OF TRANSFORMING GROWTH FACTOR β1 ON PROLIFERATION AND MIGRATION ABILITY OF BLADDER CANCER CELLS AND ITS MECHANISM [PDF]

精准医学杂志, 2023
Objective To investigate the effect of transforming growth factor β1 (TGF-β1) on the proliferation and migration ability of bladder cancer T24 cells and its mechanism. Methods T24 cells were treated with TGF-β1 at concentrations of 0, 1, 5, 10, 20 and 40
CHEN Xinlei, YU Yongbo, LI Peng, NIU Haitao
doaj   +1 more source

Alternative immune checkpoints in immunoregulatory profile of cancer stem cells

Heliyon, 2023
Tumor-mediated bypass of immune checkpoint inhibitor (ICI) therapy with anti-programmed death-1 (PD-1), anti-programmed death-ligand 1 (PD-L1, also called B7–H1 or CD274) or anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a challenge of ...
Keywan Mortezaee, Jamal Majidpoor
doaj   +1 more source

CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. [PDF]

PLoS ONE, 2011
The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability, are now appreciated for their role in initiating and
D'Anne S Duncan, Stephen D Miller
doaj   +1 more source

B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. [PDF]

PLoS Pathogens, 2009
Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are ...
Trupti Joshi, Susana Rodriguez, Vladimir Perovic, Ian A Cockburn, Simona Stäger   +4 more
doaj   +1 more source

Inhibition of colorectal cancer targets IL-6, CTLA-4, & B7-2 by Tislelizumab: molecular docking, dynamics, & STRING protein-protein network analysis

Informatics in Medicine Unlocked, 2023
As a DNA mismatch repair deficit (dMMR) anticancer medication, and a humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years.
Mahmoud Elkazzaz, Shahid Ullah, Tianshun Gao, Israa M. Shamkh, Amr Ahmed, Ted X. Wu, Maii S. Elsharayidi, Mohammad Shahbaz Khan, Aziz-ur Rehman, Marwa M. Lotfy, Abdullah Haikal, Mahmoud Abdalrahman   +11 more
doaj   +1 more source

Expression of programmed cell death ligand-1 and mismatch repair status in endometrial carcinomas

Journal of Mid-Life Health, 2023
Background and Aims: Programmed death ligand-1 (PD-L1) is a co-regulatory molecule that suppresses local immunity, and mismatch repair (MMR) deficiency (dMMR) is reported to influence the response to anti-PD-L1-targeted therapy.
Madhubala Rajendran, Meenakshi Rao, Poonam Abhay Elhence, Jyotsna Naresh Bharti, Pratibha Singh, Garima Yadav, Aasma Nalwa, Akhil Dhanesh Goyal   +7 more
doaj   +1 more source

Immunoexpression of PD-L1, CD4+ and CD8+ cell infiltrates and tumor-infiltrating lymphocytes (TILs) in the microenvironment of actinic cheilitis and lower lip squamous cell carcinoma

Journal of Applied Oral Science, 2022
Lower lip squamous cell carcinomas (LLSCC) could be associated with a previous history of potentially malignant oral diseases (PMOD), especially actinic cheilitis (AC), with high sun exposure being a well-described risk factor. Immune evasion mechanisms,
Vinícius Gonçalves de Souza, Damilys Joelly Souza Santos, Ana Gabriela Silva, Rosy Iara Maciel de Azambuja Ribeiro, Adriano Mota Loyola, Sérgio Vitorino Cardoso, Carla Silva Siqueira Miranda, Ludimila Paula Vaz Cardoso   +7 more
doaj   +1 more source

Engineered CAR-T-Derived Exosomes Co-Delivering miR-145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy. [PDF]

J Extracell Vesicles
ABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Yang R, Wang H, Wang G, Yuan G, Wei Z, An J, Hu D, Wen W, Gao S, Wan Y, Liang G.   +10 more
europepmc   +2 more sources