Results 11 to 20 of about 545,026 (158)

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

Blood, 2010
Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance.
Fukaya, Tomohiro, Takagi, Hideaki, Sato, Yumiko, Sato, Kaori, Eizumi, Kawori, Taya, Honami, Shin, Tahiro, Chen, Lieping, Dong, Chen, Azuma, Miyuki, Yagita, Hideo, Malissen, Bernard, Sato, Katsuaki   +12 more
openaire   +4 more sources

B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. [PDF]

PLoS Pathogens, 2009
Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are ...
Trupti Joshi, Susana Rodriguez, Vladimir Perovic, Ian A Cockburn, Simona Stäger   +4 more
doaj   +1 more source

Inhibition of colorectal cancer targets IL-6, CTLA-4, & B7-2 by Tislelizumab: molecular docking, dynamics, & STRING protein-protein network analysis

Informatics in Medicine Unlocked, 2023
As a DNA mismatch repair deficit (dMMR) anticancer medication, and a humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years.
Mahmoud Elkazzaz, Shahid Ullah, Tianshun Gao, Israa M. Shamkh, Amr Ahmed, Ted X. Wu, Maii S. Elsharayidi, Mohammad Shahbaz Khan, Aziz-ur Rehman, Marwa M. Lotfy, Abdullah Haikal, Mahmoud Abdalrahman   +11 more
doaj   +1 more source

Expression of programmed cell death ligand-1 and mismatch repair status in endometrial carcinomas

Journal of Mid-Life Health, 2023
Background and Aims: Programmed death ligand-1 (PD-L1) is a co-regulatory molecule that suppresses local immunity, and mismatch repair (MMR) deficiency (dMMR) is reported to influence the response to anti-PD-L1-targeted therapy.
Madhubala Rajendran, Meenakshi Rao, Poonam Abhay Elhence, Jyotsna Naresh Bharti, Pratibha Singh, Garima Yadav, Aasma Nalwa, Akhil Dhanesh Goyal   +7 more
doaj   +1 more source

Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistence [PDF]

Laboratory Investigation, 2016
B7-H1 binding to programmed death-1 may deliver a coinhibitory signal to T cells that is involved in the regulation of T-cell activation and tolerance. B7-H1 plays a key role in dysfunction of dendritic cells (DCs) during chronic HBV infection, but the expression mechanism of B7-H1 remains unclear.
Man, Li, Zhen-Hua, Zhou, Xue-Hua, Sun, Xin, Zhang, Xiao-Jun, Zhu, Shu-Gen, Jin, Ya-Ting, Gao, Yun, Jiang, Yue-Qiu, Gao   +8 more
openaire   +2 more sources

Immunoexpression of PD-L1, CD4+ and CD8+ cell infiltrates and tumor-infiltrating lymphocytes (TILs) in the microenvironment of actinic cheilitis and lower lip squamous cell carcinoma

Journal of Applied Oral Science, 2022
Lower lip squamous cell carcinomas (LLSCC) could be associated with a previous history of potentially malignant oral diseases (PMOD), especially actinic cheilitis (AC), with high sun exposure being a well-described risk factor. Immune evasion mechanisms,
Vinícius Gonçalves de Souza, Damilys Joelly Souza Santos, Ana Gabriela Silva, Rosy Iara Maciel de Azambuja Ribeiro, Adriano Mota Loyola, Sérgio Vitorino Cardoso, Carla Silva Siqueira Miranda, Ludimila Paula Vaz Cardoso   +7 more
doaj   +1 more source

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

OncoImmunology, 2020
The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously targeting antigen and the solid tumor microenvironment are two major factors that greatly impact CAR ...
Baozhu Huang, Liqun Luo, Jun Wang, Bailin He, Rui Feng, Na Xian, Qiong Zhang, Lieping Chen, Gangxiong Huang   +8 more
doaj   +1 more source

Targeting the PD-1/PD-L1 Axis in Human Vitiligo

Frontiers in Immunology, 2020
Autoreactive CD8+ T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can ...
Marcella Willemsen, Cornelis J. M. Melief, Marcel W. Bekkenk, Rosalie M. Luiten   +3 more
doaj   +1 more source

Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells

Haematologica, 2013
Clinical trials of immunotherapy in mantle cell lymphoma have not yet delivered desirable results, partly because of the inhibitory machinery of the tumor and its microenvironment.
Lijuan Wang, Jianfei Qian, Yong Lu, Haiyan Li, Hanying Bao, Donghua He, Zhiqiang Liu, Yuhuan Zheng, Jin He, Yi Li, Sattva Neelapu, Jing Yang, Larry W. Kwak, Qing Yi, Zhen Cai   +14 more
doaj   +1 more source

Immunohistochemical Expression of Programmed Death Ligand-1 in Tumour Milieu of Oral Cancer

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2020
Objectives: To determine the immunohistochemical expression of PD-L1 in oral squamous cell carcinoma and to correlate it with clinicopathological parameters.
Moomal Aslam Khan, Serajuddaula Syed, Noor Ul Wahab, Saima Akram Butt   +3 more
doaj   +1 more source