Efficient Dendritic Cell Maturation and Initiation a Strong T Cell Immune Response Requires B7-H1-Mediated Dendritic Cell ‘Conditioning’ During Interaction with T Cells [PDF]
, 2008 One of the prominent features of the adaptive immune system is the extensive interactions between T cells and dendritic cells (DCs). The T cell-DC interactions are essential for T cell development, homeostasis, and activation, and require two signals ...
Talay, Oezcan
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Clinical significance of the costimulatory molecule b7-h1 in barrett carcinoma.
, 2011 The costimulatory molecule B7-H1 (programmed death-1 ligand-1, PD-L1) has been implicated as a potential regulator of antitumor immunity in various human cancers. To date, no data are available on the role of B7-H1 in Barrett carcinoma.
Loos, M;Langer, R;Schuster, T;Gertler, R;Walch, A;Rauser, S;Friess, H;Feith, M
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Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice
Molecular Carcinogenesis, Volume 65, Issue 6, Page 677-686, June 2026.ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh +3 more
wiley +1 more source
Identification of B7-H1 and PD-1 expressing T cellsinfiltrated in human oral squamous cell carcinoma
, 2010 在口腔中超過95%的惡性腫瘤為口腔鱗狀上皮細胞癌，並且為台灣六大常見侵襲癌症死因之ㄧ。人類產生在不同器官或組織的癌症，其疾病起因除了基因毒性和致癌基因突變外，免疫編輯(immune-editing)也被視為一個重要的因素，目前已經有研究指出調節性T細胞(Tregs)和表現抑制性B7分子的細胞對於腫瘤微環境的免疫抑制以及腫瘤生長都有貢獻。在本論文中發現口腔癌腫瘤組織抑制性B7-H1分子和調節性T細胞的表現相關性，接著分析口腔癌病人表現抑制性B7-H1分子的腫瘤浸潤調節性T細胞。研究發現腫瘤組織CD4 ...
Ou, Yu-Chih, 歐育志
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Regulation of the B7-H1 (CD274) inhibitory molecule expression on tumour and immune cells. [PDF]
, 2011 The co-stimulatory/inhibitory molecules of family B7 that are expressed on the surface of antigen-presenting and other cells, including tumour cells, play an important role in immune responses regulations.
Hrušková, Veronika
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B7-H1 Expressed by Activated CD8 T Cells Is Essential for Their Survival
, 2011 An immunoinhibitory role of B7 homologue 1 (B7-H1) expressed by non-T cells has been established; however, the function of B7-H1 expressed by T cells is not clear.
Vesna Pulko +7 more
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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers [PDF]
, 2016 Background: Resistance to chemotherapy is a major obstacle in the effective treatment of cancer patients. B7-homolog 1, also known as programmed death ligand-1 (PD-L1), is an immunoregulatory protein that is overexpressed in several human cancers ...
Luketich, James D. +13 more
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Advanced Science, Volume 13, Issue 22, 17 April 2026.Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu +11 more
wiley +1 more source
, 2017 The percentages of B7-H1-positive cancer cells, as determined by double immunofluoresence, in 20 human gastric cancer samples were plotted against the levels of miR-152 (A) and miR-200b (B), as determined by qPCR. The linear regression was analyzed using
Wei Li (7081) +11 more
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B7-H1 as a new molecular target for the treatment of pancreatic adenocarcinoma [PDF]
, 2015 PDAC remains today a devastating disease characterized by a poor prognosis and low survival rates in patients. This is primarily due to its late recognition, high metastasis rates and poor response to curative therapies such as chemotherapy or radiation.
Ahn, Katharina von
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