Results 71 to 80 of about 22,112 (155)

Investigating the role of the PD-1 pathway in human ovarian cancer

, 2010
Tumours have been shown to have a number of mechanisms to suppress immunosurveillance allowing them to survive and grow. One of these mechanisms involves expression of molecules which inhibit T cells such as the molecules involved in the PD-1 pathway. PD-
Maine, Christian, Maine, Christian
core   +1 more source

On the same side: VISTA and its ligands interact in cis on the cell surface

Protein Science, Volume 35, Issue 1, January 2026.
Abstract VISTA, an essential immune checkpoint protein, regulates peripheral T‐cell quiescence and tolerance. Despite its potential as a target for anti‐tumor and autoimmune disease therapies, uncertainty regarding VISTA's binding mode and membrane orientation has hindered the development of these therapies.
Karina Smorodinsky‐Atias, Gil Wiseglass, Alina Artyukhova, Mariana Salem, Maya Kashani, Nadir Boni, Rachel Levy, Rotem Rubinstein   +7 more
wiley   +1 more source

The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer [PDF]

, 2018
Programmed death 1 (PD-1) is a co-inhibitory receptor in the CD28/CTL-4 family, and functions as a negative regulator of the immune system. Tumor-infiltrating lymphocytes (TIL) in many epithelial cancers express PD-1, suggesting that antitumor immunity ...
Gao, F., Gillanders, W., Muenst, S., Obermann, E., Oertli, D., Soysal, S.   +5 more
core  

Use of archival versus newly collected tumor samples for assessing PD-L1 expression and overall survival : an updated analysis of KEYNOTE-010 trial

, 2019
Background: In KEYNOTE-010, pembrolizumab versus docetaxel improved overall survival (OS) in patients with programmed death-1 protein (PD)-L1-positive advanced non-small-cell lung cancer (NSCLC).
Ahn, M-J, Baas, P, de Castro, G, Jr, Dubos Arvis, C, Emancipator, K, Felip, E, Fidler, MJ, Garon, EB, Garrido, M, Han, J-Y, Herbst, RS, Jensen, EH, Kim, D-W, Kim, J-H, Lubiniecki, GM, Majem, M, Molina, JR, Perez-Gracia, JL, Samkari, A, Shentu, Y, Surmont, Veerle   +20 more
core   +1 more source

Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma. [PDF]

, 2016
In order to evaluate the correlation of B7-H4 and B7-H1 with renal cell carcinoma (RCC), we analyzed B7-H1 and B7-H4 expressions and their clinical significance by immunohistochemical method. Our result indicated that B7-H4-positive staining was detected
Ahmadi, Koorosh., Ghaderi, Omar., Mohammadi, Mohsen., Rahmani, Omid., Rostamzadeh, Ayoob., Safaei, Hamid Reza., Yahaghi, Hamid.   +6 more
core  

Poster Session 3

Pregnancy, Volume 2, Issue S1, January 2026.
wiley   +1 more source

Glial cell functions in CNS homeostasis and local immune regulation Zur [PDF]

, 2015
Schreiner, B
core   +1 more source

A New VISTA on combination therapy for negative checkpoint regulator blockade [PDF]

, 2016

core   +1 more source

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus. [PDF]

iScience
Xiao ZX, Liang R, Hu X, Huang C, Nie J, Xie C, Wang J, Fang Q, Fan X, Olsen N, Zhou L, Li B, Zheng SG.   +12 more
europepmc   +1 more source

Development and characterization of a novel B7-H3 rabbit monoclonal antibody for glioma diagnosis. [PDF]

Front Pharmacol
Li Y, Wang Z, Wen Q, Chiu M, Jia X, Li Y, Shang X.   +6 more
europepmc   +1 more source