Results 141 to 150 of about 1,284,058 (379)

Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells [PDF]

, 2007
Laurent Vallat, Yuhyun Park, Cheng Li, John G. Gribben   +3 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Recent Findings of the Types of Programmed Cell Death [PDF]

, 2017
Sylwia Borys, Ronza Khozmi, Wiesława Kranc, Artur Bryja, Marta Dyszkiewicz-Konwińska, Michal Ješeta, Bartosz Kempisty   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death–Ligand 1 Interaction as Potential Anticancer Agents

, 2020
Binbin Cheng, Yichang Ren, Xiaoge Niu, Wei Wang, Shuanghu Wang, Yingfeng Tu, Shuwen Liu, Jin Wang, Deying Yang, Guochao Liao, Jianjun Chen   +10 more
openalex   +1 more source

Endothelial Apoptosis in Pulmonary Hypertension Is Controlled by a microRNA/Programmed Cell Death 4/Caspase-3 Axis [PDF]

, 2014
Kevin P. White, Yvonne Dempsie, Paola Caruso, Emma Wallace, Robert A. McDonald, Hannah Stevens, Mark E. Hatley, Eva van Rooij, Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker   +10 more
openalex   +1 more source

Glial Cell Line-Derived Neurotrophic Factor and Developing Mammalian Motoneurons: Regulation of Programmed Cell Death Among Motoneuron Subtypes

, 2021
Ronald W. Oppenheim, Lucien J. Houenou, Alexender S. Parsadanian, David Prevette, William D. Snider, Liya Shen   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer [PDF]

, 2019
Yiming Li, Jingmin Yu, Zhenyu Liu, Hai‐Jiao Yang, Juan Tang, Zhi‐Nan Chen   +5 more
openalex   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources