Results 171 to 180 of about 1,266,471 (355)

Endothelial Apoptosis in Pulmonary Hypertension Is Controlled by a microRNA/Programmed Cell Death 4/Caspase-3 Axis [PDF]

, 2014
Kevin P. White, Yvonne Dempsie, Paola Caruso, Emma Wallace, Robert A. McDonald, Hannah Stevens, Mark E. Hatley, Eva van Rooij, Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker   +10 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells [PDF]

, 2007
Laurent Vallat, Yuhyun Park, Cheng Li, John G. Gribben   +3 more
openalex   +1 more source

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

Journal of Clinical Oncology, 2018
H. Rizvi, F. Sánchez-Vega, Konnor C. La, Walid K. Chatila, P. Jonsson, D. Halpenny, A. Plodkowski, N. Long, J. Sauter, N. Rekhtman, T. Hollmann, K. Schalper, J. Gainor, R. Shen, A. Ni, K. Arbour, T. Merghoub, J. Wolchok, A. Snyder, J. Chaft, M. Kris, C. Rudin, N. Socci, M. Berger, B. Taylor, A. Zehir, D. Solit, M. Arcila, M. Ladanyi, Gregory Riely, N. Schultz, M. Hellmann   +31 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Yeast programmed cell death and ageing

Frontiers in Oncology, 2013
Manuela eCôrte-Real, Frank eMadeo
doaj   +1 more source

Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors

, 2017
Carmelo Tibaldi, Alice Lunghi, Editta Baldini   +2 more
openalex   +2 more sources

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Glial Cell Line-Derived Neurotrophic Factor and Developing Mammalian Motoneurons: Regulation of Programmed Cell Death Among Motoneuron Subtypes

, 2000
Ronald W. Oppenheim, Lucien J. Houenou, Alexender S. Parsadanian, David Prevette, William D. Snider, Liya Shen   +5 more
openalex   +2 more sources

Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts [PDF]

, 2016
Dallas Jones, Anna Blackmon, C. Preston Neff, Brent E. Palmer, Don Gilden, Hussain Badani, Maria A. Nagel   +6 more
openalex   +1 more source