Results 341 to 350 of about 560,147 (362)

The machinery of programmed cell death

Pharmacology & Therapeutics, 2001
Apoptosis or programmed cell death is an essential physiological process that plays a critical role in development and tissue homeostasis. However, apoptosis is also involved in a wide range of pathological conditions. Apoptotic cells may be characterized by specific morphological and biochemical changes, including cell shrinkage, chromatin ...
Katja C. Zimmermann, Christine Bonzon, Douglas R. Green   +2 more
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Programmed Cell Death

2006
Apoptosis is a physiological process of cell suicide that is implemented by activation of latent proteases that demolish vital cellular constituents. Apoptosis is used to sculpt the body during development, to maintain constant cell number by balancing cell production by mitosis, and to remove cells that are damaged or infected.
Andreas Strasser, David L. Vaux
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Erythrocyte programmed cell death

IUBMB Life, 2008
AbstractEryptosis, the suicidal death of erythrocytes, is characterised by cell shrinkage, membrane blebbing and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Phosphatidylserine‐exposing erythrocytes are recognised by macrophages, which engulf and degrade the affected cells.
Stephan M. Huber, Michael Föller, Florian Lang   +2 more
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Programmed cell death in the germline

Seminars in Cell & Developmental Biology, 2005
In many organisms, programmed cell death of germ cells is required for normal development. This often occurs through highly conserved events including the transfer of vital cellular material to the growing gametes following death of neighboring cells. Germline cell death also plays a role in such diverse processes as removal of abnormal or superfluous ...
Jason Baum, Kimberly McCall, J.P. St. George   +2 more
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Programmed cell death in trypanosomatids

Parasitology Today, 1997
It has generally been assumed that apoptosis and other forms of programmed cell death evolved to regulate growth and development in multicellular organisms. However, recent work has shown that some parasitic protozoa have evolved a cell suicide pathway analogous to the process described as apoptosis in metazoa.
Gwyn T. Williams, Susan C. Welburn, Marcello A. Barcinski   +2 more
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Programmed cell death in plants

Biochemistry (Moscow), 2012
The modern concepts of programmed cell death (PCD) in plants are reviewed as compared to PCD (apoptosis) in animals. Special attention is focused on considering the potential mechanisms of implementation of this fundamental biological process and its participants.
Raisa A. Galiullina, R. E. Beloshistov, Alexander I. Tuzhikov, A. S. Fomicheva, Andrey B. Vartapetian, Nina V. Chichkova, Svetlana V Trusova, L. V. Mochalova   +7 more
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The Origin of Programmed Cell Death [PDF]

Science, 1996
Cells from multicellular organisms self-destruct when they are no longer needed. Ameisen describes how such programmed cell death has now been found in lower organisms and what this tells us about evolution of the process of cell death.
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Programmed cell death and the caspases

APMIS, 1999
Members of a family of cysteine proteases known as caspases orchestrate the intracellular biochemical events that enable animal cells to kill themselves by apoptosis. To counteract the apoptotic response to infection, some viruses have adapted and evolved proteins that specifically block caspases. More recently, it has been demonstrated that endogenous
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Programmed cell death and the proteasome

Apoptosis, 1998
A characteristic feature of apoptotic cell death is the activation of a cascade of cytoplasmic proteases that results in the cleavage of a limited number of target proteins. A central role in these proteolytic events has been assigned to members of the capase family.
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Serpins and Programmed Cell Death

1997
Cell death is a normal feature of animal development. Studies on a number of cell types, such as neurons that die during growth of young animal nervous systems and lymphocytes that die during receptor repertoire selection in adults, have shown that cells usually kill themselves by activating built in suicide mechanisms1. In mature organisms cell number
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