Results 41 to 50 of about 1,461,401 (232)
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Development of a game-based learning tool for applied team science communication in a virtual clinical trial. [PDF]
, 2018 Educational tools for application of team science competencies in clinical research are needed. Our interdisciplinary group developed and evaluated acceptability of a virtual world game-based learning tool simulating a multisite clinical trial ...
Depp, Colin A +5 more
core +1 more source
Computer Architectures to Close the Loop in Real-time Optimization [PDF]
, 2015 © 2015 IEEE.Many modern control, automation, signal processing and machine learning applications rely on solving a sequence of optimization problems, which are updated with measurements of a real system that evolves in time.
Constantinides, GA +4 more
core +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Collaborative learning using Microworld and WebMapQuest [PDF]
, 2004 The intention of this paper is to show relevant issues (resulting from theoretical and empiric research) about how Microworld can be used to elicit the building of knowledge and to encourage collaborative learning.
Okada, Alexandra
core
Breadth First Search Vectorization on the Intel Xeon Phi
, 2016 Breadth First Search (BFS) is a building block for graph algorithms and has recently been used for large scale analysis of information in a variety of applications including social networks, graph databases and web searching.
Lujan, Mikel +2 more
core +1 more source
Proceedings of the Eleventh Workshop on Logic Programming Environments (WLPE'01) [PDF]
arXiv, 2001 The Eleventh Workshop on Logic Programming Environments (WLPE'01) was one in a series of international workshops in the topic area. It was held on December 1, 2001 in Paphos, Cyprus as a post-conference workshop at ICLP 2001. Eight refereed papers were presented at the conference.
arxiv
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
About Instruction Sequence Testing [PDF]
arXiv, 2012 Software testing is presented as a so-called theme within which different authors and groups have defined different subjects each of these subjects having a different focus on testing. A uniform concept of software testing is non-existent and the space of possible coherent perspectives on software testing, each fitting within the theme, is viewed as ...
arxiv
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source