Results 141 to 150 of about 10,065,028 (360)
Parents’ Perceptions Regarding the Implementation of a Physical Therapy Stimulation Program for Children with Disabilities in Bolivia: A Qualitative Study [PDF]
, 2020 Sagrario Pérez‐de la Cruz +1 more
openalex +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Logic Programming for Describing and Solving Planning Problems
, 2000 A logic programming paradigm which expresses solutions to problems as stable models has recently been promoted as a declarative approach to solving various combinatorial and search problems, including planning problems.
Bruynooghe, Maurice
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
, 2012 Martin Jínek +5 more
openalex +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Bid Landscape Forecasting and Cold Start Problem With Transformers
IEEE AccessIn Real-Time Bidding, advertisers aim to optimally bid within a limited budget constraint. Effective bidding strategies require bid landscape forecasting to predict the probability distribution of market price for each advertisement auction.
Daria Yakovleva +3 more
doaj +1 more source