Results 201 to 210 of about 10,065,028 (360)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Digital composites with reprogrammable phase architectures. [PDF]

Sci Adv
Bai Y, Yuan X, Weng Y, Yin K, Wang H, Ni X.   +5 more
europepmc   +1 more source

HOUSING AS NEW INCOME TO HOUSEOWNER THROUGH HOMESTAY PROGRAM: DOES THIS TYPE OF ENTREPRENEUR READY?

, 2020
Maisarah Mohd Rabu, Norngainy Mohd Tawil, Hasnat Ahmad, Abid Hussain   +3 more
openalex   +1 more source

Enzymatic, but not non‐enzymatic, ¹O₂‐mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1‐dependent stress response program in the flu mutant of Arabidopsis thaliana [PDF]

, 2008
Dominika Przybyla, Cornelia Göbel, André Imboden, Mats Hámberg, Ivo Feußner, Klaus Apel   +5 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Free summer programming on elementary-aged children's food and beverage consumption: a randomized clinical trial. [PDF]

Int J Behav Nutr Phys Act
Savidge MC, Burkart S, Pfledderer CD, Adams EL, Weaver RG, Armstrong B, Brazendale K, Zhu X, Chen B, McLain A, Beets MW.   +10 more
europepmc   +1 more source

A Programmable Prompting Device Improves Adherence to Highly Active Antiretroviral Therapy in HIV-Infected Subjects with Memory Impairment [PDF]

, 2005
Adriana Andrade, Henraya McGruder, Albert W. Wu, Shivaun A. Celano, Richard L. Skolasky, Ola A. Selnes, I‐Chan Huang, Justin C. McArthur   +7 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Local field potentials survey to guide DBS programming in Parkinson's disease: a clinical-neurophysiological longitudinal study. [PDF]

NPJ Parkinsons Dis
D'Onofrio V, Weis L, Rigon L, Ciprietti D, Grassi LL, Landi A, Porcaro C, Tinkhauser G, Antonini A, Guerra A.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source