HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
The maternal-infant microbiome axis as an epigenetic and immunometabolic orchestrator: redefining early-life programming and precision interventions for lifelong women's and children's health. [PDF]
Mukherjee A.
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Pruning random resistive memory for optimizing analog AI. [PDF]
Li Y +22 more
europepmc +1 more source
Enhancing Computational Thinking and Programming Logic Skills with App Inventor 2 and Robotics: Effects on Learning Outcomes, Motivation, and Cognitive Load. [PDF]
Huang YT, Li CL, Chang CC, Tarng W.
europepmc +1 more source
High-concurrency tri-mode memristor-based ordinary differential equation solver. [PDF]
Yu L +12 more
europepmc +1 more source
Fabricating liquid crystal actuators: from small pre-strain to large actuation strain. [PDF]
He E +10 more
europepmc +1 more source

