Results 271 to 280 of about 10,065,028 (360)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Programming pulse width dependent charge retention characteristics of low-power synaptic thin film transistors. [PDF]

Sci Rep
Cha D, Pi J, Lee S.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Fatty Acid Optimization of Locally Produced Ready-to-Use Therapeutic Foods for the Treatment of Acute Malnutrition in Children Using Linear Programming: An Application to India and Pakistan. [PDF]

Nutrients
Ismail S, Umesh A, Khan M, Moutwakil A, Nguyen T, Dantuluri M, Annadanam A, Prasad A, Multra M, Sudhakar D, Mahadevan V, Khan GN, Soofi S, West KP.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RasGRP1 signaling is required for Vγ2+ thymocyte c-Maf expression and γδT17 lineage programming. [PDF]

J Immunol
Joannou K, Golec DP, Azad AK, Henao Caviedes LM, May JF, Kelly RG, Baldwin TA.   +6 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Shape programming of liquid crystal elastomers by two-stage wavelength-selective photopolymerization.

Mater Horiz
Bruining T, Tomé DR, Liu D.
europepmc   +1 more source

Enhanced programming efficiency in vertical NAND flash using self-boosting hot carrier injection. [PDF]

Sci Rep
Kim M, Hong J, Kim C, Kim SJ, Hwang S, Baik SJ, Jeon J.   +6 more
europepmc   +1 more source