Results 71 to 80 of about 29,738 (264)

Wybe: Design of a Programming Language

open access: yesSoftware
We propose a set of design principles to guide the design of a programming language intended for general, practical use. These principles center around supporting the development of robust programs, supporting independent development, the evolution of ...
Peter Schachte
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Mediated Transfer in Teaching Programming Using Visual Programming Languages [PDF]

open access: yesPolitehnika, 2018
Novice programmers find learning programming difficult and challenging. That perception has a negative effect on motivation, and problems which students face during their first learning attempts only confirm their expectations so they give up.
Divna Krpan, Damir Brčić
doaj  

The overview of software for computer simulations in profile physics learning

open access: yesCTE Workshop Proceedings, 2019
The paper deals with the possibilities of using specialized (virtual labs and simulators, software for natural process simulation) and general (programming languages and libraries, spreadsheets, CAS) software in school researches.
Arnold E. Kiv   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Accuracy Optimization of Robotic Machining Using Grey-Box Modeling and Simulation Planning Assistance

open access: yesJournal of Manufacturing and Materials Processing
The aim of this paper is to develop an approach to increase the accuracy of industrial robots for machining processes. During machining tasks, process forces displace the end effector of the robot.
Minh Trinh   +5 more
doaj   +1 more source

Visual Dataflow Language for Educational Robots Programming

open access: yesТруды Института системного программирования РАН, 2018
Visual domain-specific languages usually have low entry barrier. Sometimes even children can program on such languages by working with visual representations.
G. A. Zimin, D. A. Mordvinov
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

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