Results 141 to 150 of about 4,027,257 (319)

Environmental Earth Sciences Progress Report 2020 and Outlook 2021. [PDF]

Environ Earth Sci, 2021
Kolditz O, Teti P, Dörhöfer G, LaMoreaux J, Andriani GF, Appleyard S, Asch T, Buttafuoco G, Dietrich P, Hursthouse A, Kim D, Merkel BJ, Schwarzbauer J, Siegesmund S, Kolditz B.   +14 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Montana cooperative elk-logging study : progress report for the period January 1-December 31, 1976 /

, 1977
Eugene O. Allen, Joseph V. Basile, Reuel G. Janson, Terry N. Lonner, L. Jack Lyon, C. Les Marcum, Floyd. Pond, Robert R. Ream, Darrell. Sall, Montana Cooperative Elk-Logging Study., Montana Cooperative Elk-Logging Study., Montana., United States., United States.   +13 more
openalex   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Social organization for improved system management and sustainable irrigated agriculture in small dams: an action research program. Yearly progress report, 1 April 1997 to 31st March 1998 on DFID-Funded Action Research Project [PDF]

, 1998
M. A. Cheema, D. J. Bandaragoda
openalex  

Spacelike and Timelike Compton Scattering: Progress report [PDF]

, 2012
H. Moutarde, F. Sabatié
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Update Report on Progress of COVID-19 Pandemic from 19th-25th January, 2022 Across Different Countries of the World [PDF]

, 2023
Joseph Oyepata Simeon, Joseph Opeyemi Tosin, Sabastine Aliyu Zubairu   +2 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source