Results 11 to 20 of about 5,027,565 (330)

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

open access: yesFrontiers in Immunology, 2021
Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer   +16 more
doaj   +1 more source

Persistent progress [PDF]

open access: yesCell, 2021
The highly effective and safe mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines draw on decades of painstaking research to overcome the many hurdles for delivering, expressing, and avoiding toxicity of therapeutic mRNA. Cell editor Nicole Neuman talked with Dr. Katalin Karikó and Dr.
openaire   +2 more sources

Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives

open access: yesBiology, 2021
(1) Background: Tumors of the peritoneal serosa are called peritoneal carcinosis. Their origin may be primary by primitive involvement of the peritoneum (peritoneal pseudomyxoma, peritoneal mesothelioma, etc.). This damage to the peritoneum can also be a
Niki Christou   +7 more
doaj   +1 more source

Building a progression culture: exploring learning organisations’ use of the Progression Matrix [PDF]

open access: yes, 2011
This research paper explores the implementation of The Progression Matrix in schools, colleges and other learning organisations such as training providers.
Hooley, Tristram, Moore, Nicki
core   +2 more sources

PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer

open access: yesCancer & Metabolism, 2022
Background Resistance to chemotherapeutic drugs is a key factor for cancer recurrence and metastases in head and neck cancer (HNC). Cancer stem cells (CSCs) in tumors have self-renewal, differentiation, and higher drug resistance capabilities, resulting ...
Wan-Hsuan Sun   +4 more
doaj   +1 more source

Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. [PDF]

open access: yes, 2015
BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events.
Blaha, Michael J   +7 more
core   +2 more sources

Tumor Hybrid Cells: Nature and Biological Significance

open access: yesFrontiers in Cell and Developmental Biology, 2022
Metastasis is the leading cause of cancer death and can be realized through the phenomenon of tumor cell fusion. The fusion of tumor cells with other tumor or normal cells leads to the appearance of tumor hybrid cells (THCs) exhibiting novel properties ...
Maria S. Tretyakova   +4 more
doaj   +1 more source

Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis [PDF]

open access: yes, 2017
BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesions and relapses during the first year of treatment predict a poor prognosis.
Dahdaleh, S   +5 more
core   +1 more source

Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells

open access: yesNeoplasia: An International Journal for Oncology Research, 2008
Analyzing the growth of fibrosarcoma lines derived from IL-1α–, IL-1β–, or IL-1αβ–knockout (−/−) mice in the immunocompetent host revealed that tumor-derived IL-1α and IL-1β exert strong and opposing effects on immune response induction, which prohibited
Irina Nazarenko   +9 more
doaj   +1 more source

Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. [PDF]

open access: yes, 2017
Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer ...
Abouharb, Sausan   +12 more
core   +2 more sources

Home - About - Disclaimer - Privacy