Results 21 to 30 of about 2,483,222 (269)
Frontiers in Immunology, 2021 Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer +16 more
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Biology, 2021 (1) Background: Tumors of the peritoneal serosa are called peritoneal carcinosis. Their origin may be primary by primitive involvement of the peritoneum (peritoneal pseudomyxoma, peritoneal mesothelioma, etc.). This damage to the peritoneum can also be a
Niki Christou +7 more
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Progress in Progression? [PDF]
Journal of the American Society of Nephrology, 2010 Diabetic nephropathy is the major cause of ESRD in the United States.1 Unfortunately, only angiotensin-converting enzyme inhibitors or angiotensin type 1 receptor blockers are registered for slowing the progression of diabetic nephropathy—but they do not halt progression.2–5 Given that diabetic nephropathy costs the health care system close to $30 ...
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Cancer & Metabolism, 2022 Background Resistance to chemotherapeutic drugs is a key factor for cancer recurrence and metastases in head and neck cancer (HNC). Cancer stem cells (CSCs) in tumors have self-renewal, differentiation, and higher drug resistance capabilities, resulting ...
Wan-Hsuan Sun +4 more
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Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells
Neoplasia: An International Journal for Oncology Research, 2008 Analyzing the growth of fibrosarcoma lines derived from IL-1α–, IL-1β–, or IL-1αβ–knockout (−/−) mice in the immunocompetent host revealed that tumor-derived IL-1α and IL-1β exert strong and opposing effects on immune response induction, which prohibited
Irina Nazarenko +9 more
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Tumor Hybrid Cells: Nature and Biological Significance
Frontiers in Cell and Developmental Biology, 2022 Metastasis is the leading cause of cancer death and can be realized through the phenomenon of tumor cell fusion. The fusion of tumor cells with other tumor or normal cells leads to the appearance of tumor hybrid cells (THCs) exhibiting novel properties ...
Maria S. Tretyakova +4 more
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Heliyon, 2020 Somatic mutations of the estrogen receptor 1 gene (ESR1) is an emerging mechanism of acquired resistance to endocrine therapy in hormonal breast cancers.
David Barua +3 more
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The miR-17-92 cluster: Yin and Yang in human cancers
Cancer Treatment and Research Communications, 2022 MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis.
Wenyuan Zhao +3 more
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
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Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation
Life Science Alliance, 2023 This work shows that an increase in intracellular ROS through the Rac1–NOX pathway is a general response upon loss of cell–cell adhesion, which is necessary for triggering cell migration.
Yu-Hsuan Chen +6 more
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