Results 21 to 30 of about 5,027,565 (330)

XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation

open access: yesHeliyon, 2020
Somatic mutations of the estrogen receptor 1 gene (ESR1) is an emerging mechanism of acquired resistance to endocrine therapy in hormonal breast cancers.
David Barua   +3 more
doaj   +1 more source

The miR-17-92 cluster: Yin and Yang in human cancers

open access: yesCancer Treatment and Research Communications, 2022
MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis.
Wenyuan Zhao   +3 more
doaj   +1 more source

The impact of perceived school climate on exercise behavior engagement among obese adolescents: a dual mediation effect test of exercise benefits and perseverance qualities

open access: yesFrontiers in Psychology, 2023
IntroductionThis study explores the relationship between perceived school climate and exercise behavior among obese adolescents, as well as the multiple mediating effects of perseverance qualities and exercise benefits.MethodsA survey was conducted on ...
Yao Yin   +4 more
doaj   +1 more source

Progress in Progression? [PDF]

open access: yesJournal of the American Society of Nephrology, 2010
Diabetic nephropathy is the major cause of ESRD in the United States.1 Unfortunately, only angiotensin-converting enzyme inhibitors or angiotensin type 1 receptor blockers are registered for slowing the progression of diabetic nephropathy—but they do not halt progression.2–5 Given that diabetic nephropathy costs the health care system close to $30 ...
openaire   +1 more source

Intraocular Pressure Fluctuation: Is It Important? [PDF]

open access: yes, 2018
Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of glaucoma. Previous prospective, randomized, long-term studies have demonstrated the strength of IOP reduction in slowing the progression of disease.
Caprioli, Joseph, Kim, Ji Hyun
core   +2 more sources

Teaching progressions and learning progressions [PDF]

open access: yesBiochemistry and Molecular Biology Education, 2019
AbstractJust as students undergo “learning progressions” in moving from naivety to mastery of biochemical topics, faculty experience “teaching progressions” as they experiment with pedagogy, listen to students' feedback, and become members of a community of educators. An important element of both teaching and learning is assessment.
openaire   +2 more sources

IFNα and IFNγ Impede Marek’s Disease Progression [PDF]

open access: yes, 2019
Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D.   +6 more
core   +1 more source

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

open access: yesCells, 2019
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer   +3 more
doaj   +1 more source

Front progression for the East model [PDF]

open access: yes, 2013
The East model is a one-dimensional, non-attractive interacting particle system with Glauber dynamics, in which a flip is prohibited at a site $x$ if the right neighbour $x+1$ is occupied.
Blondel, Oriane
core   +1 more source

Progressive Thoughts about Progressive Disease [PDF]

open access: yesClinical Cancer Research, 2007
In this issue of Clinical Cancer Research , Desai et al. ([1][1]) present evidence that new modules appearing in preexisting lesions can represent clonally resistant populations. Imatinib mesylate, the prototypic oral tyrosine kinase inhibitor that has activity against ABL, KIT, and platelet-
openaire   +2 more sources

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