Results 171 to 180 of about 701,268 (244)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Prognostic Nutritional Index enhances risk stratification and predicts progression-free survival in upper tract urothelial carcinoma. [PDF]

Discov Oncol
Li G, Zheng W, Zhang X, Jia J.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Sex Impacts Progression-Free Survival of Alectinib through Drug Exposure in Patients with <i>ALK-</i>Positive Non-Small Cell Lung Cancer. [PDF]

Cancer Commun (Lond)
Lanser DAC, Heersche N, Muntinghe-Wagenaar MB, Ali MIM, Ulas EB, de Jonge E, Hoop EO, Paats MS, Bahce I, Croes S, Langen AJ, Hendriks LEL, Wekken AJ, Huitema ADR, Schaik RHN, Dingemans AC, Veerman GDM, Mathijssen RHJ.   +17 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Combined neutrophil-to-lymphocyte ratio and nomogram for predicting progression-free survival in recurrent/metastatic cervical cancer treated with immune checkpoint inhibitors. [PDF]

Front Immunol
Xu Z, Zhang L, Wang H, Li X, Qian W, Zhao Z, Yang K, Bai G.   +7 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Stereotactic ablative radiotherapy-driven immunosuppression is associated with poorer progression-free survival in cancer patients. [PDF]

Cancer Immunol Immunother
Oliver J, Reed H, Capitani L, Poon-King A, Young A, Milutinovic S, Kuczynski M, Nicholas O, Rackley T, Pembroke C, Godkin A, Gallimore AM.   +11 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Impact of Achieving Progression-Free Survival 24 on Subsequent Overall Survival in Diffuse Large B-Cell Lymphoma Patients. [PDF]

Cancer Sci
Fujimoto A, Munakata W, Ogawa G, Machida R, Suzuki T, Shimada K, Kobayashi T, Ohmachi K, Kinoshita T, Ando K, Maruyama D, Nagai H.   +11 more
europepmc   +1 more source