Results 111 to 120 of about 82,833 (333)

Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View

Frontiers in Immunology, 2018
The increased use of newer potent immunomodulatory therapies for multiple sclerosis (MS), including natalizumab, fingolimod, and dimethyl fumarate, has expanded the patient population at risk for developing progressive multifocal leukoencephalopathy (PML)
E. Mills, Y. Mao-Draayer
semanticscholar   +1 more source

Drug Interaction With Advanced Therapies in Inflammatory Bowel Diseases: A Blind Spot to Tackle

United European Gastroenterology Journal, EarlyView.
Nathan Grellier, Julien Kirchgesner
wiley   +1 more source

Recrudescence of Natalizumab‐Induced Pneumonitis and Peripheral Hypereosinophilia: Case Report and Literature Review

Respirology Case Reports, Volume 13, Issue 4, April 2025.
We report a rare case of recrudescence of natalizumab‐induced pneumonitis and peripheral hypereosinophilia, thereby uniquely satisfying the re‐exposure principle outlined by the Naranjo Adverse Drug Reaction Probability Scale. This strengthens the evidence of rare but serious side effects of natalizumab, emphasising the importance of monitoring for ...
Gerardo Arwi, Louis Chhor, Vivek Malipatil   +2 more
wiley   +1 more source

Towards Multifocal Displays with Dense Focal Stacks [PDF]

, 2018
We present a virtual reality display that is capable of generating a dense collection of depth/focal planes. This is achieved by driving a focus-tunable lens to sweep a range of focal lengths at a high frequency and, subsequently, tracking the focal length precisely at microsecond time resolutions using an optical module.
arxiv   +1 more source

A case of immune reconstitution syndrome complicating progressive multifocal leukoencephalopathy after kidney transplant: Clinical, pathological, and radiographic features [PDF]

, 2019
Progressive multifocal leukoencephalopathy (PML) is a life‐threatening central nervous system (CNS) disorder, most commonly described in patients infected with the human immunodeficiency virus (HIV).
Bogdanovich, Tatiana, Chen, Huiwen, Doyle, John, Haidar, Ghady, Jackowiak, Eric, Ojha, Ajitesh, Shah, Nirav, Shepler, Anne, Silveira, Fernanda P.   +8 more
core   +1 more source

Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis

Frontiers in Oncology, 2019
The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade,
L. Del Valle, S. Piña‐Oviedo
semanticscholar   +1 more source

Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab

Annals of Neurology, Volume 97, Issue 3, Page 583-595, March 2025.
Objective B‐cell–depletion via CD20 antibodies is a safe and effective treatment for active relapsing multiple sclerosis (RMS). Both ocrelizumab (OCR) and ofatumumab (OFA) have demonstrated efficacy in randomized controlled trials and are approved for treatment of RMS, yet nothing is known on their comparative effectiveness, especially in the real ...
Sven G. Meuth, Stephanie Wolff, Anna Mück, Alice Willison, Konstanze Kleinschnitz, Saskia Räuber, Marc Pawlitzki, Franz Felix Konen, Thomas Skripuletz, Matthias Grothe, Tobias Ruck, Hagen B. Huttner, Christoph Kleinschnitz, Tobias Bopp, Refik Pul, Bruce A. C. Cree, Hans‐Peter Hartung, Kathrin Möllenhoff, Steffen Pfeuffer   +18 more
wiley   +1 more source

Pembrolizumab for progressive multifocal leukoencephalopathy due to primary immunodeficiency

Neurology: Neuroimmunology & Neuroinflammation, 2019
Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disease of the CNS, which develops almost exclusively in immunocompromised patients and is caused by JC virus (JCV), a common polyomavirus.1 So far, treatment efficacy is ...
C. Küpper, Johanna Heinrich, K. Kamm, Veit L Bücklein, S. Rothenfusser, A. Straube   +5 more
semanticscholar   +1 more source

Glycerophospholipids: Roles in Cell Trafficking and Associated Inborn Errors

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT Glycerophospholipids (GPLs) are the main lipid components of cellular membranes. They are implicated in membrane structure, vesicle trafficking, neurotransmission, and cell signalling. GPL molecules are amphiphilic, organized around the three carbons of glycerol. Positions sn‐1 and sn‐2 are each esterified to a fatty acid (FA).
Foudil Lamari, Francis Rossignol, Grant A. Mitchell   +2 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in an immunocompetent patient [PDF]

Annals of Clinical and Translational Neurology, 2016
AbstractProgressive multifocal leukoencephalopathy (PML), a demyelinating disease of the brain, is typically diagnosed in immunocompromised persons. Here, we describe the diagnostic challenge of PML in an apparently immunocompetent patient. Thorough analyses, including cytokine release assays and whole exome sequencing, revealed a deficit in the ...
Brigit A. de Jong, Brigit A. de Jong, Alexander Hoischen, Mihai G. Netea, Ingeborg W.M. van Uden, Peer Arts, Frank L. van de Veerdonk, Nicolien M. van der Kolk   +7 more
openaire   +7 more sources