Results 121 to 130 of about 82,833 (333)

Progressive multifocal leukoencephalopathy treated with interleukin-7

Clinical Infection in Practice, 2020
Background: Progressive multifocal leukoencephalopathy (PML) is a rare devastating brain infection caused by the JC polyomavirus (JCPyV) in patients with impaired cellular immune responses. In the absence of effective anti-viral therapy, it is unclear if
Karl B. Alstadhaug, Christine Hanssen Rinaldo, Liv Osnes, Irini Sereti, Hilde K. Ofte   +4 more
doaj  

Multifocality and recurrence risk: a quantitative model of field cancerization [PDF]

arXiv, 2013
Primary tumors often emerge within genetically altered fields of premalignant cells that appear histologically normal but have a high chance of progression to malignancy. Clinical observations have suggested that these premalignant fields pose high risks for emergence of secondary recurrent tumors if left behind after surgical removal of the primary ...
arxiv  

Adaptive optics for multifocal plane microscopy [PDF]

arXiv, 2020
Multifocal plane microscopy (MUM) allows three dimensional objects to be imaged in a single camera frame. Our approach uses dual orthogonal diffraction phase gratings with a quadratic distortion of the lines to apply defocus to the first diffraction orders which, when paired with a relay lens, allows for 9 focal planes to be imaged on a single camera ...
arxiv  

The Incidence and Predisposing Factors of John Cunningham Virus-Induced Progressive Multifocal Leukoencephalopathy in Southern Finland : A Population-Based Study [PDF]

, 2019
Background. The aim of this study was to assess the prevalence, incidence rate (IR), predisposing factors, survival rate, and diagnostic delay of progressive multifocal leukoencephalopathy (PML) across medical specialties. Another objective was to survey
Anttila, Veli-Jukka, Janes, Rita, Kartau, Marge, Lappalainen, Maija, Paetau, Anders, Palomäki, Maarit, Ristola, Matti, Verkkoniemi-Ahola, Auli   +7 more
core   +1 more source

Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

Emerging Infectious Diseases, 2019
Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients.
Chloé Médrano, F. Vergez, C. Mengelle, S. Faguer, N. Kamar, A. Del Bello   +5 more
semanticscholar   +1 more source

Defining benefit: Clinically and biologically meaningful outcomes in the next‐generation Alzheimer's disease clinical care pathway

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract To understand the potential benefits of emerging Alzheimer's disease (AD) therapies within and beyond clinical trial settings, there is a need to advance current outcome measurements into meaningful information relevant to all stakeholders. The relationship between the impact on disease biology and clinically measurable outcomes in cognition ...
Aya Elhage, Sharon Cohen, Jeffrey Cummings, Wiesje M. van der Flier, Paul Aisen, Min Cho, Joanne Bell, Harald Hampel   +7 more
wiley   +1 more source

Towards Occlusion-Aware Multifocal Displays [PDF]

arXiv, 2020
The human visual system uses numerous cues for depth perception, including disparity, accommodation, motion parallax and occlusion. It is incumbent upon virtual-reality displays to satisfy these cues to provide an immersive user experience. Multifocal displays, one of the classic approaches to satisfy the accommodation cue, place virtual content at ...
arxiv  

Incidence and Outcome of Progressive Multifocal Leukoencephalopathy over 20 Years of the Swiss HIV Cohort Study [PDF]

, 2017
Background. We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996 ...
Battegay, Manuel, Bernasconi, Enos, Cavassini, Matthias, Elzi, Luigia, Fux, Christoph A., Garzoni, Christian, Hirsch, Hans H., Khanna, Nina, Mueller, Nicolas J., Vernazza, Pietro   +9 more
core  

Evolving Patterns of Initial RRMS Treatment in Finland (2013–2022): Insights From a Nationwide Multiple Sclerosis Register

Brain and Behavior, Volume 15, Issue 2, February 2025.
ABSTRACT Background The treatment of relapsing‐remitting multiple sclerosis (RRMS) is changing. There are limited data about initial treatment of RRMS in Finland. Objective Our objectives were to study the trends of initial disease‐modifying treatments (DMTs) for patients with RRMS from 2013 to 2022, treatment delays, factors associated with DMT choice,
Henrik Ahvenjärvi, Elina Jokinen, Matias Viitala, Henri Autio, Anne M. Portaankorva, Merja Soilu‐Hänninen, Johanna Krüger, Mervi Ryytty   +7 more
wiley   +1 more source

Effectiveness of Cidofovir in Treating Natalizumab-Associated Progressive Multifocal Leukoencephalopathy (PML) [PDF]

, 2021
Natalizumab (Nz) a monoclonal antibody has been in medicinal use for treatment of Relapsing Remitting Multiple Sclerosis (RRMS) since 2004. Progressive Multifocal Leukoencephalopathy (PML) is one of its serious risks which is a demyelinating disorder of ...
Mansoor, Salman
core   +1 more source