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Progressive Multifocal Leukoencephalopathy [PDF]

open access: yesNeurologic Clinics, 2018
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the ...
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Progressive Multifocal Leukoencephalopathy

Seminars in Neurology, 1999
Before the AIDS epidemic, progressive multifocal leukoencephalopathy (PML) was a rare disorder occurring most often in association with leukemia and lymphoma. Current estimates indicate that PML ultimately develops in up to 5% of all patients with AIDS.
Eugene O Major
exaly   +3 more sources

Progressive Multifocal Leukoencephalopathy

Neurologic Clinics, 1984
PML is a progressive opportunistic infection of the CNS caused by a commonly occurring virus that may become manifest in the context of reduced host resistance in persons of any age. The authors review the disease and its causes, including a discussion of treatment attempts and differential diagnoses.
B R, Brooks, D L, Walker
openaire   +2 more sources

Progressive Multifocal Leukoencephalopathy

Journal of Neuroscience Nursing, 1982
A 32-year-old man had biopsy-proven progressive multifocal leukoencephalopathy (PML) and long-standing sarcoidosis. Treatment with several courses of cytarabine failed, and the patient died of the neurologic disease. Reports of therapeutic experiences in PML are summarized.
A, Minnick, A J, Oleson
openaire   +4 more sources

Progressive Multifocal Leukoencephalopathy

Radiology, 1976
The radionuclide, radiographic and pathologic findings in a patient with progressive multifocal leukoencephalopathy were correlated. Radionuclide imaging demonstrated the largest two of the many lesions observed at pathology. On repeated studies, one of the lesions developed a "doughnut" sign due to central necrosis. Cerebral angiography disclosed only
J, Kirsh   +3 more
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Progressive Multifocal Leukoencephalopathy

Archives of Internal Medicine, 1963
Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease apparently resulting from the selective destruction of oligodendrocytes by papovaviruses. The pathology and pathogenesis of PML are distinct from those of the other slow infections of the human nervous system.
R F, JOHNSTON   +2 more
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Progressive multifocal leukoencephalopathy

Current Infectious Disease Reports, 2001
Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts.
Anna R., Thorner, Joel T., Katz
openaire   +2 more sources

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