Results 131 to 140 of about 33,332 (299)

Imaging tau pathology in Parkinsonisms

open access: yesnpj Parkinson's Disease, 2017
The recent development of positron emission tomography radiotracers targeting pathological tau in vivo has led to numerous human trials. While investigations have primarily focused on the most common tauopathy, Alzheimer’s disease, it is imperative that ...
Sarah Coakeley, Antonio P. Strafella
doaj   +1 more source

Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

open access: yesEuropean Journal of Neurology, Volume 32, Issue 11, November 2025.
Objective: Heart rate variability (HRV) is a promising tool for autonomic dysfunction assessment, especially Deceleration capacity (DC), a sensitive parasympathetic marker. M&M: Study in patients with isolated REM sleep behavior disorder, Parkinson's disease, multiple system atrophy, and supranuclear palsy as compared to healthy control subjects ...
Elisabeth Ruppert   +9 more
wiley   +1 more source

Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
Synthetic neuromelanin analogs are used to characterize iron and copper binding to the melanin moiety or to conjugated protein (β‐lactoglobulin). The models confirm the presence of paramagnetic mononuclear‐binding sites and iron or mixed‐metal clusters that enhance water proton relaxation to varying degrees.
Niklas Wallstein   +11 more
wiley   +1 more source

Proton magnetic resonance spectroscopy in Parkinson's disease and progressive supranuclear palsy. [PDF]

open access: bronze, 1997
Francesco Federico   +7 more
openalex   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, Volume 599, Issue 19, Page 2718-2749, October 2025.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1962-1970, October 2025.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono   +8 more
wiley   +1 more source

NORTRIPTYLINE FOR THE TREATMENT OF DEPRESSION IN PROGRESSIVE SUPRANUCLEAR PALSY [PDF]

open access: bronze, 1997
Sérgio Tamai   +2 more
openalex   +1 more source

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

open access: yesAggregate, Volume 6, Issue 10, October 2025.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute   +2 more
wiley   +1 more source

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