Results 131 to 140 of about 34,277 (277)
Imaging tau pathology in Parkinsonisms
npj Parkinson's Disease, 2017 The recent development of positron emission tomography radiotracers targeting pathological tau in vivo has led to numerous human trials. While investigations have primarily focused on the most common tauopathy, Alzheimer’s disease, it is imperative that ...
Sarah Coakeley, Antonio P. Strafella
doaj +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang +8 more
wiley +1 more source
Genotype–phenotype interaction in Alzheimer's disease immune activation
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder influenced by genetic factors, particularly related to immune activation. This study examines genotype‐phenotype interactions affecting immune responses in AD as a reaction to neurodegeneration.
Stephanie Knudtzon +18 more
wiley +1 more source
Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsy [PDF]
, 2020 Talisa Silzer +2 more
openalex +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Tau species lacking truncation of the N‐terminal region, including plasma N‐terminal tau fragment 1 (NT1), have been previously associated with cognitive decline, neurodegeneration, and tau pathology in late‐onset sporadic Alzheimer's disease (AD). METHODS Here, we examined cross‐sectional and longitudinal plasma NT1 as a possible
Stephanie A. Schultz +26 more
wiley +1 more source
Alzheimer's disease polygenic risk in early‐ and late‐onset Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION The genetic basis of sporadic early‐onset Alzheimer's disease (EOAD) remains largely unknown, prompting evaluation of late‐onset Alzheimer's disease (LOAD) polygenic risk in EOAD. METHODS A LOAD polygenic score (PGS) was calculated in the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS) and Alzheimer's Disease ...
Julian V. Pentchev +56 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs +11 more
wiley +1 more source
Postural Stabilization Differences in Idiopathic Parkinson’s Disease and Progressive Supranuclear Palsy during Self-Triggered Fast Forward Weight Lifting [PDF]
, 2018 Stefan Kammermeier +7 more
openalex +1 more source
Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 120-130, January 2026.This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori +15 more
wiley +1 more source