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The neuropathology of progressive supranuclear palsy
1994The macroscopical, histological, ultrastructural and immunocytochemical features of progressive supranuclear palsy (PSP) are reviewed. Recent investigations have revealed important differences in the distribution, ultrastructure and immunocytochemical profile of neurofibrillary tangles in PSP and in Alzheimer's disease.
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Update on progressive supranuclear palsy
Current Neurology and Neuroscience Reports, 2004A better understanding of the challenges in the diagnosis of progressive supranuclear palsy (PSP), the most common atypical parkinsonian neurodegenerative disorder, has led to improving its diagnostic accuracy. Similarly, a better understanding of the role of tau mutations, mitochondrial complex I inhibitors, oxidative injury, and inflammation in ...
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The Epidemiology of Progressive Supranuclear Palsy
2008Publisher Summary This chapter describes that the incidence of progressive supranuclear palsy (PSP) is approximately 1 per 100,000 and the prevalence is approximately 5 per 100,000. Most patients ascertained by such community-based surveys were not previously diagnosed as having PSP, testament to the low sensitivity to the diagnosis on the part of ...
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Progressive Supranuclear Palsy: an Update
Current Neurology and Neuroscience Reports, 2018Progressive supranuclear palsy (PSP) is a 4R tau neuropathologic entity. While historically defined by the presence of a vertical supranuclear gaze palsy and falls in the first symptomatic year, clinicopathologic studies identify alternate presenting phenotypes.
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[Sleep in progressive supranuclear palsy].
Rivista di patologia nervosa e mentale, 1982Nocturnal sleep was poligraphycally recorded in three male patients aged 54-67, with progressive supranuclear palsy (PSP). All patients suffered from insomnia. In case 1 REM sleep was markedly reduced and spindles were less numerous than in normal subjects.
Massetani R +4 more
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Neuropathology of Progressive Supranuclear Palsy
2008Publisher Summary This chapter describes progressive supranuclear palsy (PSP) as an atypical parkinsonian disorder associated with progressive axial rigidity, vertical gaze palsy, dysarthria, and dysphagia. A frontal lobe syndrome and subcortical dementia are present in some cases.
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Clinical Conditions “Suggestive of Progressive Supranuclear Palsy”—Diagnostic Performance
Movement Disorders, 2020John Van Swieten +2 more
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Prediagnostic Progressive Supranuclear Palsy – Insights from the UK Biobank
Parkinsonism and Related Disorders, 2022James Rowe +2 more
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