Results 101 to 110 of about 148,737 (346)

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An, Yuhao Wu, Jingzhe Han, Pingping Fang, Yi Bu, Guang Ji, Jinliang Deng, Xueqin Song   +7 more
wiley   +1 more source

Autologous hematopoietic stem-cell transplantation in diffuse cutaneous systemic sclerosis: a single-center experience

Reumatismo
Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by multisystem involvement. Patients can be stratified into an indolent or rapidly progressive disease course.
Marko Barešić, Ljiljana Smiljanić Tomičević, Igor Aurer, Mislav Cerovec, Branimir Anić   +4 more
doaj   +1 more source

Scleroderma renal crisis in tropical region: two senegalese cases

The Pan African Medical Journal, 2015
Scleroderma renal crisis (SRC) is defined as the new onset of accelerated arterial hypertension and /or rapidly progressive oliguric renal failure during the course of systemic sclerosis. It is a rare but life-threatening complication.
Mouhamadou Moustapha Cisse, Sidy Mohamed Seck, Daher Abdoul Karim Oumar, Khodia Fall, Ahmed Tall Lemrabott, Moussa Diallo, Maria Faye, Moustapha Faye, Abdou Niang, Boucar Diouf   +9 more
doaj   +1 more source

Subcutaneous immunoglobulin therapy for refractory skin thickening in rapidly progressive systemic sclerosis: A case report and literature review. [PDF]

J Scleroderma Relat Disord, 2023
Cacciapaglia F, Stano S, Fornaro M, Iannone F.   +3 more
europepmc   +1 more source

Some Immunologic Considerations in Focal Scleroderma and Progressive Systemic Sclerosis in Children [PDF]

, 1974
Virgil Hanson, Helen Kornreich, Elizabeth Drexler, Gerald D. Johnson, G A MacPherson   +4 more
openalex   +1 more source

Understanding the Housing and Support Experience of People With Complex Disability in Australia: A Qualitative Analysis of Submissions to the Disability Royal Commission

Australian Journal of Social Issues, EarlyView.
ABSTRACT In 2019, the Australian government established the Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability (‘Disability Royal Commission’, DRC) to investigate widespread mistreatment of people with disability. Nearly 10,000 people with disability, their families and supporters engaged with the DRC.
Kate D'Cruz, Fiona Carey, Libby Witts, Jessie Spence, Peter Mulherin, Megan Topping, Di Winkler, Jacinta Douglas   +7 more
wiley   +1 more source

Intrathecal, Not Systemic Inflammation Is Correlated With Multiple Sclerosis Severity, Especially in Progressive Multiple Sclerosis

Frontiers in Neurology, 2019
Objective: To test the hypothesis that Multiple Sclerosis (MS) patients have increased peripheral inflammation compared to healthy donors and that this systemic activation of the immune system, reflected by acute phase reactants (APRs) measured in the ...
Joshua L. Milstein, Christopher R. Barbour, Kayla Jackson, Peter Kosa, Bibiana Bielekova   +4 more
doaj   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang, Yufei Li, Lin Zhang, Zhaoqing Li, Keqin Lin, Kai Huang, Zhaoqing Yang, Shaohui Ma, Hao Sun, Xiaochao Zhang   +9 more
wiley   +1 more source

Scleroderma and scleroderma-like syndromes

Frontiers in Immunology
Systemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved.
Katarzyna Romanowska-Próchnicka, Martyna Dziewit, Aleksandra Lesiak, Adam Reich, Marzena Olesińska   +4 more
doaj   +1 more source

A case of progressive systemic sclerosis/lupus overlap syndrome: Presenting with parotid swelling. [PDF]

J Oral Maxillofac Pathol, 2021
Ramya R, Swarnalakshmi R, Preethi A, Pradeep R.   +3 more
europepmc   +1 more source