Results 101 to 110 of about 116,133 (341)

Arterial pathology in canine mucopolysaccharidosis-I and response to therapy. [PDF]

, 2011
Mucopolysaccharidosis-I (MPS-I) is an inherited deficiency of α-L-iduronidase (IdU) that causes lysosomal accumulation of glycosaminoglycans (GAG) in a variety of parenchymal cell types and connective tissues.
Dickson, Patricia I, Ellinwood, N Matthew, Kakkis, Emil D, Lyons, Jeremiah A, McEntee, Michael F, Passage, Merry B, Wall, Jonathan S   +6 more
core   +3 more sources

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression

, 2013
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).
Friede, Tim, Nicholas, Richard, Röver, Christian, Schneider, Simon, Steinvorth, Simon M., Straube, Sebastian   +5 more
core   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Evaluation of dystrophic calcification in juvenile dermatomyositis and systemic sclerosis

Acta Pediátrica de México, 2014
Background: Dystrophic calcification is associated with juvenile dermatomyositis and progressive systemic sclerosis. The clinical diagnosis is established with detection of subcutaneous and petrous nodules.
Marimar Saez-de Ocariz
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Copeptin as a Biomarker of Microcirculation Alterations in Systemic Sclerosis

Clinical, Cosmetic and Investigational Dermatology, 2023
Magdalena Maciejewska,1 Albert Stec,2 Michał Zaremba,2 Cezary Maciejewski,3 Lidia Rudnicka,2 Mariusz Sikora4 1Department of Dermatology, Doctoral School of Medical University of Warsaw, Warsaw, Poland; 2Department of Dermatology, Medical ...
Maciejewska M, Stec A, Zaremba M, Maciejewski C, Rudnicka L, Sikora M   +5 more
doaj  

Serum interleukin-6 level and its association with pulmonary involvement in progressive systemic sclerosis; a case-control study. [PDF]

Clin Mol Allergy, 2023
Piroozmand A, Zamani B, Haddad Kashani H, Amini Mahabadi J.   +3 more
europepmc   +1 more source

Serial pulmonary function tests in progressive systemic sclerosis. [PDF]

, 1979
L.R. Bagg, David T. Hughes
openalex   +1 more source