Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party. [PDF]
Haematologica, 2021 Three randomized controlled trials in early severe systemic sclerosis demonstrated that autologous hematopoietic stem cell transplantation was superior to standard cyclophosphamide therapy.
Henes J +22 more
europepmc +2 more sources
Acta Dermato-Venereologica, 2014 Angiopoietin-like protein 3 (ANGPTL3), which is part of a family of secreted glycoproteins that are structurally similar to angiopoietins, is principally expressed in the liver and is involved in lipid metabolism and angiogenesis.
Yohei Ichimura +14 more
openalex +2 more sources
Systemic sclerosis: key clinical features of a rare and progressive disease. [PDF]
Pan Afr Med JTikariha A.
europepmc +2 more sources
State-of-the-art evidence in the treatment of systemic sclerosis
Nature Reviews Rheumatology, 2023 Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous SSc (dcSSc) and the use of organ-specific therapies, has improved, as ...
J. Pope +5 more
semanticscholar +1 more source
Tocilizumab combined with cyclophosphamide for the treatment of rapidly progressive refractory systemic sclerosis with predominant cardiac involvement: a case report. [PDF]
Front ImmunolFu ZC +5 more
europepmc +2 more sources
The role of trigger factors in the development of systemic sclerosis (clinical case)
Современная ревматология, 2023 A clinical case of the development of rapidly progressive systemic sclerosis after repeated coronavirus infection is described. The contribution of occupational hazards, the oncological process and radiation therapy to the pathogenesis of this disease is
I. V. Menshikova +3 more
doaj +1 more source
Progressive systemic sclerosis in the elderly [PDF]
Postgraduate Medical Journal, 1979 Summary There is evidence to suggest that the incidence of progressive systemic sclerosis in the elderly is more common than in younger age groups. As in younger patients, late onset cases may have minimal skin changes and this can cause difficulty in diagnosis. The case histories of 2 patients are presented to illustrate these points.
Dalziel, J, Wilcock, G
openaire +4 more sources
Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need
Nature Reviews Rheumatology, 2022 Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and treatment of potentially life-threatening cardiorespiratory and ...
A. Herrick, S. Assassi, C. Denton
semanticscholar +1 more source
Annals of the Rheumatic Diseases, 2020 Objectives To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials ...
A. Hoffmann-Vold +15 more
semanticscholar +1 more source
Diagnostics, 2023 Systemic sclerosis (also known as scleroderma) is a chronic fibrosing autoimmune disease with both skin and multisystem organ involvement. Scleroderma has the highest mortality among all rheumatic diseases.
Dariana-Elena Pătrîntașu +7 more
doaj +1 more source