Results 261 to 270 of about 769,984 (331)

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

MedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie, Yuan Li, Xinyue Wang, Elena Blokhina, Evgeny Krupitsky, Marina Vetrova, Ji Hu, Ti‐Fei Yuan, Jue Chen, Hua Wang, Xiangfang Chen   +10 more
wiley   +1 more source

Risk Factors for Adverse Outcomes in Connective Tissue Disease-Associated Pulmonary Hypertension. [PDF]

Rev Cardiovasc Med
Matusov G, Shams M, Ibrahim K, Hovsepyan A, Matusov Y.   +4 more
europepmc   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
wiley   +1 more source

Progressive Myelitis in a 63-Year-Old Woman: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings. [PDF]

Neurol Neuroimmunol Neuroinflamm
DiMauro KA, Heber ME, Lee J, Cohen JA, Flanagan EP, Riley C, Goldman MD, Zamvil SS, Kunchok AC.   +8 more
europepmc   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Successful Guselkumab Treatment in a Patient with Comorbid Psoriasis and Amyotrophic Lateral Sclerosis: A Case Study and Literature Review. [PDF]

Clin Cosmet Investig Dermatol
Xiong J, Chen X, Huang K, Pan Y.
europepmc   +1 more source

All hands on deck: The multidisciplinary rehabilitation assessment and management of hand function in persons with neuromuscular disorders

Muscle &Nerve, Volume 71, Issue 5, Page 869-888, May 2025.
Abstract Hand function is important in every aspect of our lives. Across a wide range of neuromuscular disorders—inherited ataxias, motor neuron diseases, polyneuropathies, and myopathies—people can experience losses in hand strength, tone, movement, dexterity, joint range, and sensation.
Colleen O'Connell, Meiqi Guo, Béatrice Soucy, Marla Calder, Jeff Sparks, Stephanie Plamondon   +5 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in rheumatoid arthritis and biological therapies: a case report and review of the literature. [PDF]

J Med Case Rep
Bergmans B, Roks G, van Puijenbroek E, de Vries E, Murk JL.   +4 more
europepmc   +1 more source

Total Hip Arthroplasty Patients With Systemic Sclerosis Have Worse Medical Outcomes But Clinically Similar Implant Survival Independent of Immunomodulatory Therapy. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Seddio AE, Hosseini H, Vasudevan RS, Gouzoulis MJ, Rubin LE, Grauer JN.   +5 more
europepmc   +1 more source

Rationale for phosphodiesterase-4 inhibition as a treatment strategy for interstitial lung diseases associated with rheumatic diseases. [PDF]

RMD Open
Aringer M, Distler O, Hoffmann-Vold AM, Kuwana M, Prosch H, Volkmann ER.   +5 more
europepmc   +1 more source