Results 261 to 270 of about 199,652 (389)

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Clinical Images: Interstitial lung disease in Sjögren disease in association with systemic sclerosis. [PDF]

ACR Open Rheumatol
Law BM, Yockey LJ, Seyal E, Faquin WC.
europepmc   +1 more source

One Illness Always Conceals Another: A Rare Case of Renal AA Amyloidosis Secondary to Progressive Systemic Sclerosis [PDF]

Oussama Agharbi, Ayoub Jaafari, Sohaïb Mansour, Saïf-Eddine El Bouhali, Karim Bochouari, Charalampos Pierrakos, Rachid Attou   +6 more
openalex   +1 more source

Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK‐Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome

Cell Proliferation, EarlyView.
Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo, Ling Chen, Xiaoxian Zhang, Qiang Su, Xiaoya Zhou, Qizhou Lian   +5 more
wiley   +1 more source

Systemic Sclerosis-Related Interstitial Lung Disease Amid Latent Tuberculosis and Recurrent Infections. [PDF]

Cureus
Lwin NN, Hlaing WY, Sta Lucia A, Tasmin R.   +3 more
europepmc   +1 more source

Cortical hemodynamics of electrographic status epilepticus in the critically ill

Epilepsia, Volume 66, Issue 3, Page 802-816, March 2025.
Abstract Objectives The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near‐infrared spectroscopy (fNIRS) combined with video‐electroencephalography (vEEG) to monitor brain hemodynamics continuously and non‐invasively in critically ill adult ...
Ali Kassab, Dènahin H. Toffa, Manon Robert, Michaël Chassé, Frédéric Lesage, Ke Peng, Dang K. Nguyen   +6 more
wiley   +1 more source

New horizons in systemic sclerosis treatment: advances and emerging therapies in 2025. [PDF]

RMD Open
Sieiro Santos C, Del Galdo F.
europepmc   +1 more source

Neurocognitive, behavioral, and treatment burden as key predictors of parental stress in pediatric epilepsy

Epilepsia, EarlyView.
Parental stress is linked to child cognitive impairment, internalizing symptoms, complex treatments, and lower caregiver education. No gender differences were found, though most caregivers were mothers. Findings suggest the need for support beyond seizure control.
Cinzia Correale, Mattia Mercier, Simona Cappelletti, Nicola Pietrafusa, Chiara Falamesca, Elisabetta Collalti, Giusy Carfi’ Pavia, Costanza Calabrese, Marina Trivisano, Luca De Palma, Francesca Cirulli, Nicola Specchio   +11 more
wiley   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Bilateral acute retinal necrosis after ofatumumab masquerading as intermediate uveitis in a patient with multiple sclerosis. [PDF]

Am J Ophthalmol Case Rep
Ganesh P, Hojjatie RA, Arepalli S.
europepmc   +1 more source