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Diagnostics, 2023 Systemic sclerosis (also known as scleroderma) is a chronic fibrosing autoimmune disease with both skin and multisystem organ involvement. Scleroderma has the highest mortality among all rheumatic diseases.
Dariana-Elena Pătrîntașu +7 more
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Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches
Biomedicines, 2022 Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by small vessel alterations and progressive fibrosis of the skin and internal organs.
D. Benfaremo +4 more
semanticscholar +1 more source
Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis
Annals of the Rheumatic Diseases, 2021 Objectives Although T cells have been implicated in the pathogenesis of systemic sclerosis (SSc), a comprehensive study of T-cell-mediated immune responses in the affected skin of patients with progressive SSc is lacking.
A. M. Gaydosik +5 more
semanticscholar +1 more source
Rheumatology, 2019 Systemic sclerosis is an autoimmune connective tissue disease affecting both skin and internal organs. Progressive disease with multiple organ involvement is considered to have a poor prognosis.
Katarzyna Pawlak-Buś +5 more
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Sero-Negative Systemic Sclerosis: A Rare Presentation [PDF]
Journal of Clinical and Diagnostic Research, 2016 Systemic Sclerosis is a multisystem disease associated with progressive fibrosis of skin and internal organs. It is diagnosed by presence of characteristic clinical findings and is supported by specific serologic abnormalities.
Rakesh Chander +4 more
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Endothelial‐to‐mesenchymal transition in systemic sclerosis
Clinical and Experimental Immunology, 2021 Systemic sclerosis (SSc) is an autoimmune disease characterized by significant vascular alterations and multi‐organ fibrosis. Microvascular alterations are the first event of SSc and injured endothelial cells (ECs) may transdifferentiate towards ...
P. Di Benedetto +7 more
semanticscholar +1 more source
Biomarkers in systemic sclerosis. [PDF]
, 2010 Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often ...
Castro, Susan V, Jimenez, Sergio A.
core +2 more sources
Systemic sclerosis: current views of its pathogenesis. [PDF]
, 2003 Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities ...
Derk, Chris T., Jimenez, Sergio A.
core +2 more sources
Progressive Systemic Sclerosis and its Dental Implications: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2021 Scleroderma is a complex autoimmune rheumatic disease characterised by the widespread fibrosis of skin and visceral organs, dysregulation of immune system and vasculopathy. The aetiology of this disease remains unknown till now. It is known to exist in
Gor Vani Udaybhai +4 more
doaj +1 more source
A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset. [PDF]
, 2012 OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset.
Jimenez, Sergio A. +3 more
core +3 more sources