Przegląd Dermatologiczny, 2017 Systemic sclerosis is an immune-mediated disease characterized by a chronic and progressive course. It often leads to multiorgan failure and patient disability, and contributes to significant reduction in the quality of life.
Dorota Krasowska +10 more
doaj +1 more source
Pulmonary vasospasm in systemic sclerosis: noninvasive techniques for detection [PDF]
, 2014 In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea.
Giannarou, S +8 more
core +1 more source
Double Trouble in Systemic Sclerosis: Complete Heart Block and Systolic Dysfunction [PDF]
Journal of Clinical and Diagnostic Research, 2018 A 26-year-old female, a known case of diffuse systemic sclerosis present with multiple episodes of syncope and progressive dyspnoea over six months.
Akshyaya Pradhan +3 more
doaj +1 more source
Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]
, 2016 Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A. +1 more
core +2 more sources
BMC Anesthesiology, 2006 Background Systemic sclerosis (SSc), a progressive disease characterized by excessive accumulation of connective tissue components. Although most patients have long survival, some of them progress rapidly to death.
Dönmez Ferah +3 more
doaj +1 more source
Antiphospholipid Syndrome - A Case Report of Pulmonary Thromboembolism, Followed with Acute Myocardial Infarction in Patient with Systemic Sclerosis [PDF]
, 2015 AIM: We are presenting an uncommon case of pulmonary embolism, followed with an acute myocardial infarction, in a patient with progressive systemic sclerosis.
Vavlukis, Marija +6 more
core +3 more sources
Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis
Biomedicines, 2022 Systemic sclerosis (scleroderma, SSc) is one of the most challenging rheumatic diseases, characterized by vasculopathy, dysregulation of the immune response, and progressive tissue fibrosis affecting the skin, lungs, heart, digestive tract, and kidneys [.
Michal Tomcik
doaj +1 more source
Biomarkers in systemic sclerosis. [PDF]
, 2010 Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often ...
Castro, Susan V, Jimenez, Sergio A.
core +2 more sources
Redox Biology, 2019 Systemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis.
Ludivine Doridot +3 more
doaj +1 more source
Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis [PDF]
, 2018 Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental ...
Acosta, Glen +8 more
core +1 more source