Results 31 to 40 of about 148,737 (346)

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort

Annals of the Rheumatic Diseases, 2019
Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc).
Wanlong Wu, S. Jordan, N. Graf, J. de Oliveira Pena, J. Curram, Y. Allanore, M. Matucci-Cerinic, J. Pope, C. Denton, D. Khanna, O. Distler   +10 more
semanticscholar   +1 more source

Emerging treatments for scleroderma/systemic sclerosis

Faculty Reviews, 2021
Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs and has significant clinical sequelae.
Jane L. Zhu, S. Black, Henry W. Chen, H. Jacobe   +3 more
semanticscholar   +1 more source

Imaging in Diagnosis of Systemic Sclerosis

Journal of Clinical Medicine, 2021
Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis in skin and internal organs, progressive vascular obliteration, and the production of autoantibodies.
K. Rutka, A. Garkowski, K. Karaszewska, U. Łebkowska   +3 more
semanticscholar   +1 more source

Double Trouble in Systemic Sclerosis: Complete Heart Block and Systolic Dysfunction [PDF]

Journal of Clinical and Diagnostic Research, 2018
A 26-year-old female, a known case of diffuse systemic sclerosis present with multiple episodes of syncope and progressive dyspnoea over six months.
Akshyaya Pradhan, Sameer Ganpat Vankar, Pravesh Vishwakarma, Rishi Sethi   +3 more
doaj   +1 more source

Systemic sclerosis – diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1: diagnosis and monitoring

Przegląd Dermatologiczny, 2017
Systemic sclerosis is an immune-mediated disease characterized by a chronic and progressive course. It often leads to multiorgan failure and patient disability, and contributes to significant reduction in the quality of life.
Dorota Krasowska, Lidia Rudnicka, Aleksandra Dańczak-Pazdrowska, Grażyna Chodorowska, Anna Woźniacka, Anna Lis-Święty, Joanna Czuwara, Joanna Maj, Sławomir Majewski, Anna Sysa-Jędrzejowska, Anna Wojas-Pelc   +10 more
doaj   +1 more source

Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Arthritis Research & Therapy, 2018
BackgroundThe chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients ...
Florian Weigold, J. Günther, M. Pfeiffenberger, O. Cabral-Marques, E. Siegert, D. Dragun, A. Philippe, Ann-Katrin Regensburger, A. Recke, Xinhua Yu, F. Petersen, R. Catar, R. Biesen, F. Hiepe, G. Burmester, H. Heidecke, G. Riemekasten   +16 more
semanticscholar   +1 more source

Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis

Biomedicines, 2022
Systemic sclerosis (scleroderma, SSc) is one of the most challenging rheumatic diseases, characterized by vasculopathy, dysregulation of the immune response, and progressive tissue fibrosis affecting the skin, lungs, heart, digestive tract, and kidneys [.
Michal Tomcik
doaj   +1 more source

Improved pulmonary function following pirfenidone treatment in a patient with progressive interstitial lung disease associated with systemic sclerosis

Lung India, 2015
Pirfenidone is an anti-fibrotic drug which has been approved for the management of patients with Idiopathic Pulmonary Fibrosis (IPF). However, its role in interstitial lung disease (ILD) due to other causes such as systemic sclerosis (SSc) is not clear ...
Z. Udwadia, J. Mullerpattan, C. Balakrishnan, L. Richeldi   +3 more
semanticscholar   +1 more source

Acroosteolysis of distal phalanges in patient with systemic sclerosis – case report

Przegląd Dermatologiczny, 2016
Introduction. Acroosteolysis is a recognized, but under-researched and forgotten manifestation of systemic sclerosis (SSc). Objective . To present a case of exuberant acroosteolysis and subcutaneous tissue calcinosis in the course of SSc.
Zofia Gerlicz-Kowalczuk, Zbigniew Pietrzak, Jolanta D. Torzecka, Anna Woźnicka, Bożena Dziankowska-Bartkowiak   +4 more
doaj   +1 more source

Scleroderma-related interstitial lung disease

Respiratory Medicine Case Reports, 2017
Scleroderma-related interstitial lung disease (SSc-ILD) is a pulmonary fibrosing disorder characterized by systemic inflammation and progressive scarring of the lungs that leads to respiratory failure.
Sally Suliman, Abdalhamid Al Harash, William Neil Roberts, Rafael L. Perez, Jesse Roman   +4 more
doaj   +1 more source