Results 41 to 50 of about 929,362 (315)

Emerging treatments for scleroderma/systemic sclerosis

Faculty Reviews, 2021
Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs and has significant clinical sequelae.
Jane L. Zhu, S. Black, Henry W. Chen, H. Jacobe   +3 more
semanticscholar   +1 more source

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

Imaging in Diagnosis of Systemic Sclerosis

Journal of Clinical Medicine, 2021
Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis in skin and internal organs, progressive vascular obliteration, and the production of autoantibodies.
K. Rutka, A. Garkowski, K. Karaszewska, U. Łebkowska   +3 more
semanticscholar   +1 more source

Double Trouble in Systemic Sclerosis: Complete Heart Block and Systolic Dysfunction [PDF]

Journal of Clinical and Diagnostic Research, 2018
A 26-year-old female, a known case of diffuse systemic sclerosis present with multiple episodes of syncope and progressive dyspnoea over six months.
Akshyaya Pradhan, Sameer Ganpat Vankar, Pravesh Vishwakarma, Rishi Sethi   +3 more
doaj   +1 more source

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]

, 1994
A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M., Iozzo, Renato V., Jimenez, Sergio A., Rudnicka, Lidia, Uitto, Jouni, Varga, John   +5 more
core   +3 more sources

Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Arthritis Research & Therapy, 2018
BackgroundThe chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients ...
Florian Weigold, J. Günther, M. Pfeiffenberger, O. Cabral-Marques, E. Siegert, D. Dragun, A. Philippe, Ann-Katrin Regensburger, A. Recke, Xinhua Yu, F. Petersen, R. Catar, R. Biesen, F. Hiepe, G. Burmester, H. Heidecke, G. Riemekasten   +16 more
semanticscholar   +1 more source

Systemic sclerosis – diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1: diagnosis and monitoring

Przegląd Dermatologiczny, 2017
Systemic sclerosis is an immune-mediated disease characterized by a chronic and progressive course. It often leads to multiorgan failure and patient disability, and contributes to significant reduction in the quality of life.
Dorota Krasowska, Lidia Rudnicka, Aleksandra Dańczak-Pazdrowska, Grażyna Chodorowska, Anna Woźniacka, Anna Lis-Święty, Joanna Czuwara, Joanna Maj, Sławomir Majewski, Anna Sysa-Jędrzejowska, Anna Wojas-Pelc   +10 more
doaj   +1 more source

Prognostic Factors of Renal Involvement in Systemic Sclerosis [PDF]

, 2018
Background/Aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was
Barbano, Biagio, Cianci, Rosario, Gasperini, Maria Ludovica, Gigante, Antonietta, Muscaritoli, Maurizio, Rosato, Edoardo   +5 more
core   +2 more sources

Improved pulmonary function following pirfenidone treatment in a patient with progressive interstitial lung disease associated with systemic sclerosis

Lung India, 2015
Pirfenidone is an anti-fibrotic drug which has been approved for the management of patients with Idiopathic Pulmonary Fibrosis (IPF). However, its role in interstitial lung disease (ILD) due to other causes such as systemic sclerosis (SSc) is not clear ...
Z. Udwadia, J. Mullerpattan, C. Balakrishnan, L. Richeldi   +3 more
semanticscholar   +1 more source

Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis

Biomedicines, 2022
Systemic sclerosis (scleroderma, SSc) is one of the most challenging rheumatic diseases, characterized by vasculopathy, dysregulation of the immune response, and progressive tissue fibrosis affecting the skin, lungs, heart, digestive tract, and kidneys [.
Michal Tomcik
doaj   +1 more source