Results 71 to 80 of about 21,193 (336)

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

open access: yesThe Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi   +21 more
wiley   +1 more source

Estimation of Stress-Strength model in the Generalized Linear Failure Rate Distribution [PDF]

open access: yes, 2013
In this paper, we study the estimation of $R=P [Y < X ]$, also so-called the stress-strength model, when both $X$ and $Y$ are two independent random variables with the generalized linear failure rate distributions, under different assumptions about their
Daneshkhah, Alireza, Shahsanaei, Fatemeh
core  

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

A multistate model for early decision making in oncology

open access: yes, 2018
The development of oncology drugs progresses through multiple phases, where after each phase a decision is made about whether to move a molecule forward.
Beyer, Ulrich   +4 more
core   +1 more source

Completion vs. early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Chemotherapy is given for early‐stage breast cancer; however, some patients discontinue before completing all planned cycles. This study investigated the impact of early chemotherapy discontinuation on treatment outcomes. Methods This retrospective cohort study used a target trial emulation framework to conduct a causal analysis of the all‐
Luke Steventon   +9 more
wiley   +1 more source

Activism as a long durée journey: Teachers against the Chilean neoliberal education model

open access: yesBritish Educational Research Journal, EarlyView.
Abstract In this paper, I use the idea of purposes of education, particularly subjectification, and the concept of love to explore long‐term teacher activism in Chile. ‘Long‐term activism’ is used to describe an ongoing struggle rather than activism confined to specific moments.
Carla Tapia‐Parada
wiley   +1 more source

A New Multi-Progressive Generalized Type-II Censoring: Theory, Reliability Inference, and Multidisciplinary Applications

open access: yesMathematics
Modern reliability experiments frequently face operational constraints that require balancing test duration, precision, and removal strategies, rendering classical censoring schemes inadequate for contemporary multidisciplinary applications.
Heba S. Mohammed, Ahmed Elshahhat
doaj   +1 more source

Precedence-type Test based on Progressively Censored Samples [PDF]

open access: yes
In this paper, we introduce precedence-type tests for testing the hypothesis that two distribution functions are equal, which is an extension of the precedence life-test rst proposed by Nelson (1963), when the two samples are progressively Type-II ...
H. K. T. Ng   +3 more
core  

‘These reforms have teeth’: The affective dimensions of teacher education policy enactment

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The affective dimensions of education policy enactment have often received less attention in the research literature, especially regarding teacher education policy. This article reports on a study of the affective responses of university‐based teacher educators in England to the significant initial teacher education reforms of 2019–2022: the ...
Ian Cushing, Viv Ellis
wiley   +1 more source

Inference Based on Progressive-Stress Accelerated Life-Testing for Extended Distribution via the Marshall-Olkin Family Under Progressive Type-II Censoring with Optimality Techniques

open access: yesAxioms
This paper explores a progressive-stress accelerated life test under progressive type-II censoring with binomial random removal. It assumes a cumulative exposure model in which the lifetimes of test units follow a Marshall–Olkin length-biased exponential
Ehab M. Almetwally   +2 more
doaj   +1 more source

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