Results 91 to 100 of about 5,961 (310)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Impact of tax progressivity on regional income inequalities: a comparative analysis between Brazil and Germany

open access: yesBrazilian Journal of Political Economy
The progressivity of a country’s tax system can be crucial for reducing income and regional inequalities. Focusing on the cases of Germany and Brazil, in this article we analyze the tax system progressivity through an original indicator based on the ...
RAIHAN MIAN   +2 more
doaj   +1 more source

In pursuit of tax equity: lessons from VAT rate structure adjustment in Poland

open access: yesFinancial Theory and Practice, 2015
In 2011, in the aftermath of the economic crisis, Poland increased its value added tax rates. Despite an already large VAT policy gap, further rate differentiation was used to address distributional concerns and to protect the most vulnerable households.
Artur Świstak   +2 more
doaj   +1 more source

Kakwani decomposition of redistributive effect: Origins, critics and upgrades [PDF]

open access: yes
Kakwani decomposition of redistributive effect into vertical and reranking terms is one of the most widely used tools in measurement of income redistribution.
Ivica Urban
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Measurement of personal income tax progressivity in the post-socialist countries of Europe compared to other OECD countries [PDF]

open access: yesEastern Journal of European Studies, 2020
The aim of the article is to measure and analyse changes in the steepness of PIT tax progressivity in OECD countries in 2004-2017, using an alternative method of measuring the type of tax progression.
Magda WISNIEWSKA-KUZMA
doaj  

Economic ideas and redistributive policy in the Spanish parliament: the 1900 debate on fiscal progressivity [PDF]

open access: yes
This paper analyses the debate on the introduction of progressive rates in the inheritance tax, which took place in the Spanish Parliament in 1900.
Javier San-Julián-Arrupe
core  

Tax reform and progressivity

open access: yes, 2000
The established theory of tax progressivity cannot handle basic tax reform questions, such as whether an increase in personal allowances makes the tau system more progressive, because the core results assume that tax liability is never zero.
Papapanagos, Harry   +2 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

On Estimating Marginal Tax Rates and Tax Progressivities for U.S. States [PDF]

open access: yes
This research presents a simple procedure for improving state-specific estimates of marginal tax rates (MTR’s). Most research employing MTR’s follows a procedure developed by Koester and Kormendi (K&K, 1987).
W. Robert Reed   +2 more
core  

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