Results 101 to 110 of about 7,999 (309)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On Estimating Marginal Tax Rates and Tax Progressivities for U.S. States [PDF]
This research presents a simple procedure for improving state-specific estimates of marginal tax rates (MTR’s). Most research employing MTR’s follows a procedure developed by Koester and Kormendi (K&K, 1987).
W. Robert Reed +2 more
core
Optimal Tax Progressivity and Growth
, 2021 I propose an innovation-lead growth model with occupational choice to analise optimal tax progressivity. Beyond facing the classical trade-off of efficiency and redistribution, taxes can, in principle, distort participation in risk-taking ...
Rodrigues, Artur Brasil Fialho
core
Effective Taxation of Top Incomes in Germany, 1992 - 2002 [PDF]
We analyze the taxation of top personal incomes in Germany on the basis of an integrated data file of individual tax returns and a general household survey for the years 1992 - 2002.
Giacomo Corneo +2 more
core +2 more sources
Measurement of personal income tax progressivity in the post-socialist countries of Europe compared to other OECD countries [PDF]
Eastern Journal of European Studies, 2020 The aim of the article is to measure and analyse changes in the steepness of PIT tax progressivity in OECD countries in 2004-2017, using an alternative method of measuring the type of tax progression.
Magda WISNIEWSKA-KUZMA
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Economic ideas and redistributive policy in the Spanish parliament: the 1900 debate on fiscal progressivity [PDF]
This paper analyses the debate on the introduction of progressive rates in the inheritance tax, which took place in the Spanish Parliament in 1900.
Javier San-Julián-Arrupe
core
Optimal Tax Progressivity: An Analytical Framework
, 2017 What shapes the optimal degree of progressivity of the tax and transfer system? On the one hand, a progressive tax system can counteract inequality in initial conditions and substitute for imperfect private insurance against idiosyncratic earnings risk ...
Storesletten, Kjetil +2 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source