Results 121 to 130 of about 5,961 (310)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Taxation and distribution of income in Brazil: new evidence from personal income tax data
Brazilian Journal of Political Economyable This paper presents a critical analysis of income and profit taxes in Brazil, arguing that measures adopted in the 1980s and 1990s, as a result of mainstream recommendations, hindered the redistributive role of taxes.
SÉRGIO WULFF GOBETTI +1 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Indirect taxation and progressivity: revenue and welfare changes [PDF]
, 2006 Research Paper Number 930. ISSN 0819-2642, ISBN 0734025866This paper compares the disproportional effects of indirect taxation using two alternativemeasures, tax-progressivity and welfare-progressivity.
Creedy, J., Sleeman, C.
core
How to fight tax evasion: real progressivity
, 2019 The objective of this article is to discuss the issue of tax evasion in the light of real progressivity, which is pointed out as an alternative solution to the problem.
Oliveira, José André Wanderley Dantas de +1 more
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
SSM: Qualitative Research in HealthAs childhood vaccination rates are declining, healthcare professionals’ conversations with parents are increasingly important for navigating a diverse set of concerns about vaccination.
Lieve van Hengel +2 more
doaj +1 more source
Redistributive effects in a dual income tax system [PDF]
Equity issues of the dual income tax have been left aside in the field of economics. Since a dual income tax needs different modelling than a comprehensive one this paper offers firstly a quantitative framework to measure redistributive effects; it turns
Arnaldur Sölvi Kristjánsson
core
Progressivity in the Portuguese personal income tax system [PDF]
, 2016 This Work Project analyzes the evolution of the Portuguese personal income tax system’s progressivity over the period of 2005 through 2013. It presents the first computation of cardinal progressivity measures using administrative tax data for Portugal.
Martins, Ana Pedroso de Lima
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source