Results 141 to 150 of about 1,021,035 (396)
Fisetin Inhibits Hyperglycemia-Induced Proinflammatory Cytokine Production by Epigenetic Mechanisms
Evidence-Based Complementary and Alternative Medicine, 2012 Diabetes is characterized by a proinflammatory state, and several inflammatory processes have been associated with both type 1 and type 2 diabetes and the resulting complications.
Hye Joo Kim, S. Kim, Jung-Mi Yun
semanticscholar +1 more source
Nicotinamide is a potent inhibitor of proinflammatory cytokines
Clinical and Experimental Immunology, 2003 SUMMARY The present study investigates the modulating effects of nicotinamide on the cytokine response to endotoxin. In an in vitro model of endotoxaemia, human whole blood was stimulated for two hours with endotoxin at 1 ng/ml, achieving high levels of the proinflammatory cytokines IL-1β, IL-6, IL-8 and TNFα.
J. S. Ungerstedt +2 more
openaire +4 more sources
The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing
Advanced Materials, EarlyView.With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong +8 more
wiley +1 more source
IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease [PDF]
, 2008 Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors (dietary glutens) for susceptibility are known.
Alessio Fasano +2 more
core +1 more source
Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. [PDF]
, 1996 William L. Trepicchio +3 more
openalex +1 more source
Advanced Materials, EarlyView.Herein, a glutathione‐responsive system (named THN) is prepared for X‐ray‐triggered sustained ROS generation for efficient antitumor immunotherapy. The double‐promoting ROS generation of THN induced massive immunogenic cancer cell death and polarized M2 macrophages into the M1 phenotype for enhanced antitumor immunotherapy.
Qingyong Xu +10 more
wiley +1 more source
Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. [PDF]
, 2019 Tunneling nanotubes (TNTs) are cellular extensions enabling cytosol-to-cytosol intercellular interaction between numerous cell types including macrophages.
Cherqui, Stephanie +4 more
core +1 more source
Advanced Materials, EarlyView.ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac +7 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar +13 more
wiley +1 more source