Results 191 to 200 of about 1,021,035 (396)

Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice [PDF]

, 1997
J A Hobden, S. Masinick, Ronald P. Barrett, L.D. Hazlett   +3 more
openalex   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Radiation induces proinflammatory dysbiosis: transmission of inflammatory susceptibility by host cytokine induction

Gut, 2017
S. Gerassy-Vainberg, Alexandra Blatt, Y. Danin-poleg, Katya Gershovich, E. Sabo, A. Nevelsky, S. Daniel, A. Dahan, O. Ziv, Rishu Dheer, M. Abreu, O. Koren, Y. Kashi, Y. Chowers   +13 more
semanticscholar   +1 more source

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
wiley   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

Advanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang, Yuan Li, Bo Cheng, Zhao Xu, Mengjie Liu, Jinteng Feng, Yixue Bai, Yang Yu, Panpan Jiang, Luying Geng, Feng Xu, Hui Guo   +11 more
wiley   +1 more source

Nanoparticle-Mediated Delivery of Flavonoids: Impact on Proinflammatory Cytokine Production: A Systematic Review. [PDF]

Biomolecules, 2023
Stevens Barrón JC, Chapa González C, Álvarez Parrilla E, De la Rosa LA.   +3 more
europepmc   +1 more source

Proinflammatory Cytokine Modulation by Intravenous Immune Globulin (IVIG) on Ex vivo Whole Blood Assays of Young Children: Implications on Kawasaki Disease (KD) treatment † 858 [PDF]

, 1998
Rosemary Johann‐Liang, Marc Shafer, Marise McNeely, Pedro Daniel Penha, Murli Purswani, Gary J. Noel   +5 more
openalex   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source