Results 241 to 250 of about 1,021,035 (396)

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Cutaneous wound healing in type 2 diabetes db/db mice was impaired with specific changes in proinflammatory cytokine expression. [PDF]

Arch Dermatol Res
Mukai K, Iswara A, Nakatani T.
europepmc   +1 more source

Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. [PDF]

Cells, 2023
Yu YH, Kim SW, Im H, Lee YR, Kim GW, Ryu S, Park DK, Kim DS.   +7 more
europepmc   +1 more source

SYNERGY AND SPECIFICITY IN INDUCTION OF GENE ACTIVITY BY PROINFLAMMATORY CYTOKINES

, 1997
Jayne Spink, Jonathan Cohen
openalex   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes. [PDF]

Commun Biol
Wang A, Fairhurst AM, Liu K, Wakeland B, Barnes S, Malladi VS, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li QZ, Mohan C, Clayberger C, Wakeland EK, Khan S.   +21 more
europepmc   +1 more source

Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models. [PDF]

Int J Mol Sci, 2023
Sharova V, Ignatiuk V, Izvolskaia M, Zakharova L.   +3 more
europepmc   +1 more source

THE GUT LIBERATES PROINFLAMMATORY CYTOKINES AFTER INTESTINAL ISCHEMIA

, 1997
M. Grotz, Jie Ding, D. Xu, Qian Huang, G. Regel, E. A. Deitch   +5 more
openalex   +1 more source

Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma

Cancer, 2014
A. Arthur, K. Peterson, Jincheng Shen, Z. Djuric, Jeremy M G Taylor, James R. Hébert, S. Duffy, Lisa A. Peterson, E. Bellile, J. Whitfield, D. Chepeha, M. Schipper, G. Wolf, L. Rozek   +13 more
semanticscholar   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source