Results 261 to 270 of about 1,021,035 (396)

Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1

open access: yesJournal of Immunology, 2012
Yong Zhang   +6 more
semanticscholar   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

open access: yesAdvanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang   +9 more
wiley   +1 more source

Streptolysin S induces proinflammatory cytokine expression in calcium ion-influx-dependent manner. [PDF]

open access: yesCurr Res Microb Sci
Yamamori Y   +5 more
europepmc   +1 more source

Chronic stress and age-related increases in the proinflammatory cytokine IL-6

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2003
J. Kiecolt-Glaser   +5 more
semanticscholar   +1 more source

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv   +8 more
wiley   +1 more source

Genome Sequencing and Assembly of Enterotoxigenic Escherichia coli E9034A: Role of LngA, CstH, and FliC in Intestinal Cell Colonization and the Release of the Proinflammatory Cytokine IL-8. [PDF]

open access: yesMicroorganisms
Rodríguez-Martínez R   +10 more
europepmc   +1 more source

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