Results 261 to 270 of about 1,065,082 (380)

The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone. [PDF]

Int J Mol Sci
Narasimhappagari J, Liu L, Balasubramaniam M, Ayyadevara S, Aboud O, Griffin WST.   +5 more
europepmc   +1 more source

Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity [PDF]

, 1999
Christian Jobin, Cynthia A. Bradham, Maria Pia Russo, Booker Juma, Acharan S. Narula, David A. Brenner, R. Balfour Sartor   +6 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes. [PDF]

Commun Biol
Wang A, Fairhurst AM, Liu K, Wakeland B, Barnes S, Malladi VS, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li QZ, Mohan C, Clayberger C, Wakeland EK, Khan S.   +21 more
europepmc   +1 more source

Synthetic thymic hexapeptide in the correction of alterations of antibacterial immune defense and normalization of the profile of proinflammatory cytokines in immunocompromized Children with local unlimited acute peritonitis

С. В. Ковалева, V. N. Chapurina, Л. В. Ломтатидзе, D. E. Lyagusha, Yu. V. Teterin, Н. К. Барова, K. I. Melkonyan   +6 more
openalex   +2 more sources

Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II [PDF]

, 2000
A Baur, K Bauer, Hubertus Jarry, Josef Köhrle   +3 more
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Cutaneous wound healing in type 2 diabetes db/db mice was impaired with specific changes in proinflammatory cytokine expression. [PDF]

Arch Dermatol Res
Mukai K, Iswara A, Nakatani T.
europepmc   +1 more source

Are circulating proinflammatory cytokines associated with lower birth weight of newborns from women with rheumatoid arthritis? [PDF]

, 2010
Florentien D. O. de Steenwinkel, J. M. W. Hazes, Y. A. de Man, A C S Hokken, Yolanda B. de Rijke, R. Dolhain   +5 more
openalex   +1 more source

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1

Journal of Immunology, 2009
F. Bauernfeind, Gabor L Horvath, A. Stutz, E. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, Jianghong Wu, Brian G. Monks, K. Fitzgerald, V. Hornung, E. Latz   +11 more
semanticscholar   +1 more source