Results 41 to 50 of about 1,021,035 (396)

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Nature Communications, 2017
Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in ...
Lin Luo, N. Bokil, A. Wall, R. Kapetanovic, N. Lansdaal, F. Marceline, Belinda J Burgess, Samuel J Tong, Zhong Guo, K. Alexandrov, I. Ross, M. Hibbs, J. Stow, M. Sweet   +13 more
semanticscholar   +1 more source

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response [PDF]

, 2016
LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated.
Azmoon, Pardis, Brifault, Coralie, Gilder, Andrew S, Gonias, Steven L., Lam, Michael S, Mantuano, Elisabetta   +5 more
core   +1 more source

The COVID-19 Cytokine Storm; What We Know So Far

Frontiers in Immunology, 2020
COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory ...
D. Ragab, Haitham Salah Eldin, M. Taeimah, R. Khattab, R. Salem   +4 more
semanticscholar   +1 more source

MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia [PDF]

Mediators of Inflammation, 2016
Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia.
Jingjing Fan, Xianjuan Kou, Yi Yang, Ning Chen   +3 more
openaire   +4 more sources

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [PDF]

, 2018
Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair.
Achuthan, Alivernini, Alivernini, Alvaro-Gracia, Anderson, Asquith, Bamboat, Behrens, Bell, Ben Nasr, Benham, Black, Bluml, Brentano, Burmester, Burmester, Burmester, Catrina, Cauli, Cheung, Chu, Chu, Couzin-Frankel, Cramer, Cross, den Berg, den Brand, Dillon, Donlin, Ehrenstein, Elmesmari, Ferraccioli, Field, Firestein, Frank-Bertoncelj, Gao, Ginhoux, Greven, Guiducci, Guo, Hambleton, Hamilton, Haschka, Herenius, Hogg, Hurst, Iliev, James, Jongbloed, Kaplanski, Kokkonen, Kollias, Konig, Kriegler, Kurowska-Stolarska, Kurowska-Stolarska, Kurowska-Stolarska, Lemke, Malmstrom, Mann, McInnes, McInnes, McInnes, McLoughlin, Midwood, Miller, Misharin, Misso, Moret, Moret, Morton, Murata, Na, Nagy, Nassar, Ng, O'Connell, O'Connell, O'Keeffe, Ohshima, Okada, Paolino, Park, Rajasekhar, Ramwadhdoebe, Rauber, Reynolds, Roberts, Rothlin, Rupaimoole, Rycke, Sacre, Schett, Singh, Smith, Smith, Smolen, Sokolove, Stanczyk, Steidl, Takeuchi, Tannahill, Thai, Tsoumakidou, Udalova, Vandenabeele, Villani, Watts, Weinblatt, Weiss, Williamson, Wolf, Xiong, Yeo, Yu, Zou   +115 more
core   +1 more source

Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β

Frontiers in Immunology, 2023
IntroductionLomerizine is a calcium channel blocker that crosses the blood–brain barrier and is used clinically in the treatment of migraines. However, whether lomerizine is beneficial in modulating neuroinflammatory responses has not been tested yet ...
Jin-Hee Park, Jin-Hee Park, Jeong-Woo Hwang, Hyun-ju Lee, Geum Mi Jang, Yoo Joo Jeong, Yoo Joo Jeong, Joonho Cho, Jinsoo Seo, Hyang-Sook Hoe, Hyang-Sook Hoe   +10 more
doaj   +1 more source

Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease [PDF]

, 2007
Background/aim: Interleukin 31 (IL31), primarily expressed in activated lymphocytes, signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31R\textgreeka) and the oncostatin M receptor (OSMR). The aim of this study was
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, Julia, Göke, Burkhard, Haller, Dirk, Seiderer, Julia   +6 more
core   +2 more sources

Efficient Maturation and Cytokine Production of Neonatal DCs Requires Combined Proinflammatory Signals

Clinical and Developmental Immunology, 2005
Specific functional properties of dendritic cells (DCs) have been suspected as being responsible for the impaired specific immune responses observed in human neonates.
Doreen Krumbiegel, Jan Rohr, Peter Schmidtke, Markus Knuf, Fred Zepp, Claudius U. Meyer   +5 more
doaj   +1 more source

Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial

BMC Complementary and Alternative Medicine, 2018
Background There are an increasing number of evidences that chronic obstructive pulmonary disease (COPD) is a systemic illness and that bodyweight loss is its prominent manifestation.
Masao Suzuki, Shigeo Muro, Motonari Fukui, Naoto Ishizaki, Susumu Sato, Tetsuhiro Shiota, Kazuo Endo, Tomoko Suzuki, Tadamichi Mitsuma, Michiaki Mishima, Toyohiro Hirai   +10 more
doaj   +1 more source

Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production

Mediators of Inflammation, 2020
Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients.
Rui Zhu, Yan-Qing Lei, Dong-Chi Zhao
doaj   +1 more source