Results 81 to 90 of about 1,021,035 (396)

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Journal of Leukocyte Biology, 2020
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory syndrome‐coronavirus‐2 infection often results from alveolar injury that impedes airway capacity and multi‐organ failure—both of which are associated with the ...
Jin Wang, Mengmeng Jiang, Xin Chen, L. Montaner   +3 more
semanticscholar   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytes

Scientific Reports
Plasmodium falciparum infection causes the most severe form of malaria, where excessive production of proinflammatory cytokines can drive the pathogenesis of the disease.
David V. L. Romero, Thivya Balendran, Wina Hasang, Stephen J. Rogerson, Elizabeth H. Aitken, Adrian A. Achuthan   +5 more
doaj   +1 more source

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source

Effect of Perceived Stress on Cytokine Production in Healthy College Students [PDF]

, 2015
Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis.
McCarthy, Donna O., Neal, Jeremy L., Sribanditmongkol, Vorachai, Szalacha, Laura A.   +3 more
core   +1 more source

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M., Pooley, Nicholas J., Secombes, Christopher J., Tacchi, Luca   +3 more
core   +2 more sources

PATHOGENETIC ROLE OF CYTOKINES IN CHILDHOOD ROTAVIRUS INFECTION

Медицинская иммунология, 2014
. Results of cytokine network studies system in children with rotavirus infection are presented. Concentrations of cytokines were determined at both local and systemic levels.
S. N. Benyova, Ye. M. Zhidkov, Ye. V. Markelova   +2 more
doaj   +1 more source

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins

Molecular Biology of the Cell, 2014
Epithelial barriers are vital components of the innate immune system. This barrier is provided by tight junctions and compromised by proinflammatory cytokine signaling.
Christopher T. Capaldo, A. Farkas, R. Hilgarth, S. Krug, Mattie F. Wolf, Jeremy K. Benedik, M. Fromm, Michael Koval, C. Parkos, A. Nusrat   +9 more
semanticscholar   +1 more source

Observational Study of Tocilizumab in Children With Febrile Infection‐Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to assess the efficacy and safety of using tocilizumab in children with febrile infection‐related epilepsy syndrome (FIRES) and explore tocilizumab‐related changes in interleukin (IL)‐6 levels. Methods Patients with FIRES admitted to the Intensive Care Unit (ICU) of Beijing Children's Hospital were retrospectively ...
Yushan He, Jie Wu, Chaonan Fan, Zheng Li, Jun Liu, Kechun Li, Quan Wang, Suyun Qian   +7 more
wiley   +1 more source

Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 Diabetes

Journal of Diabetes Research, 2016
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting ...
Craig S. Nunemaker
doaj   +1 more source