Results 121 to 130 of about 2,538,343 (219)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A humanized eNAMPT -neutralizing monoclonal antibody reduces cancer-induced bone pain and osteoclastogenesis in murine breast cancer model. [PDF]

Front Pain Res (Lausanne)
Mathur NC, Villaroel E, Villaroel I, Liktor-Busa E, Karlage KL, Kaur M, Kempf C, Gudaite B, Ding Z, Garcia JGN, Largent-Milnes TM, Vanderah TW.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Pre-stroke frailty in patients with first-ever acute stroke: Its associations with stroke subtype and impact on activities of daily living. [PDF]

eNeurologicalSci
Iwasawa T, Aoyagi Y, Sakamoto Y, Ohashi M, Ikeda S, Saito T, Shimoyama T, Suda S.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A disynaptic trigeminal circuit for the transformation and integration of oral chemesthesis in male mice. [PDF]

Sci Adv
Liu F, Cui K, Mao J, Wang H, Li B, Guo L, Zhang N, Li Y, Ruan S, Pei W, Hao Z, Zhang Q, Chai G, Liu C, Zhang C, Wang J, Zhang S, Li L, Zhang YF, Xie J.   +19 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Ferroportin deficiency drives olaparib resistance in ovarian cancer via the cGAS-STING-STAT3 survival axis. [PDF]

Clin Transl Med
Song J, Guo Z, Yang D, Yu P, Li Y, Yuan Z, Ma X, Li X, Guo H, Xue L, Liu T.   +10 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Diagnostic Utility of Fasting Blood Glucose and Glycated Hemoglobin Compared to Oral Glucose Tolerance Test for Diabetes Mellitus: A Cross-Sectional Study. [PDF]

Health Sci Rep
Okrah E, Abdullah D, Manu B, Prah JK, Amoah S, Nyane B, Nartey GN, Ayetey ENA, Goumboundi IA, Afrifa J, Ephraim RKD.   +10 more
europepmc   +1 more source