Results 141 to 150 of about 2,538,343 (219)

Rational Drug Use Support System: design, artificial intelligence integration, and pilot feasibility trial. [PDF]

Rev Assoc Med Bras (1992)
Kahraman M, Bozkurt ME, Kotan S, Ozturk BN, Aydın R, Hatipoğlu S, Eris HA, Erturk MA, Aydin MA, Karan MA.   +9 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection. [PDF]

Langenbecks Arch Surg
Li JB, Wei W, Guo S, Li BQ, Feng Y.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Impact of molecular profiling in patients with endometrial cancer: real world experience from India. [PDF]

Front Oncol
Kaushik R, Chakraborti B, Ghosh A, Chakraborty S, Bhattacharyya T, Mishra J, Rout S, Midha D, Mishra D, Vinarkar S, Roy S, Chowdhury OR, Bhaumik J.   +12 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study. [PDF]

Clin Cancer Res
Xu T, Parseghian CM, Zhang Y, Chen Z, Qin Y, Zhang W, Deng Y, Pan H, Gu S, Li C, Ren F, Wu Y, Lu Q, Zhang M, Wang R, Zhu Y, Shen L, Li J.   +17 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Operationalizing independent oversight in large-scale public health cohorts: Monitoring protocol for the NIMHANS-NH-SKAN Stroke project. [PDF]

PLoS One
Arelingaiah M, Arun A, Madhuri BS, Akshaya KM, Anwith HS, Usha S, Holla R, Karinagannanavar A, Undi M, Holyachi S, Banandur PS, Sukumar GM, Anniappan Arvind B, Shivaraj BM, Lakshmi KS, Hegde T, Prasad K, Garady L, Ashwini A, Medhi U.   +19 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source