Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Closing the Educational Evidence Gap: A Call for Controlled Trials of Project-Based Learning in Nursing Entrepreneurship Curricula. [PDF]
Nurs Health SciWang F, Yuan J, Tang A.
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Effectiveness of integrated tuberculosis and depression treatment led by non-specialist health workers versus standard care among persons with tuberculosis in a low-resource setting: A quasi-experimental non-randomized controlled trial. [PDF]
PLOS Ment HealthMurphy-Okpala N +14 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A Quality Improvement Project to Increase Discharges before Noon at a Pediatric Hospital. [PDF]
Pediatr Qual SafWillis KC +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Community participation and operational lessons from implementing a protective coating as a novel vector control tool in dengue-endemic neighborhoods of Cúcuta and Los Patios, Colombia. [PDF]
BMC Public HealthKoo Chong S +4 more
europepmc +1 more source
Mini project : torque control of a DC motor : document transcript
, 2010 This is Mini Project documentation about torque control of a DC motor. It is part of the 2009/10 BEng in Electrical Engineering (course number 2ELE0066) from the University of Hertfordshire.
University of Hertfordshire, School of Electronic Communications and Electrical Engineering
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source