Results 191 to 200 of about 2,892,132 (356)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Assessment of the ADLIFE intervention as a digital solution for patients with advanced chronic diseases: a quasi-experimental trial. [PDF]

NPJ Digit Med
García-Lorenzo B, Gorostiza A, González N, Larrañaga I, Moro Á, Ortega-Gil A, Zubelzu B, Vega R, de La Higuera L, Kaye R, Levy G, Vishnevetsky O, Sorknæs AD, Christensen RL, Juul NK, Randeva H, Robbins T, Yorkston M, Laleci Erturkmen GB, Yuksel M, Sarigul B, Arvanitis TN, Pournik O, Tong C, Aznar-Baranda JI, Caballero-García J, Vallejo-Setién G, Lilja M, Sherman MH, Swoboda A, Groene O, Bloemeke-Cammin J, Kalra D, Maguire R, McCann L, Miller M, López NFG, de Elguea LO, Lana MÁO, Alayo I, Aguirre U, Perea BL, Yeshayahu M, Halevy ED, Panchal S, Yılmaz G, de La Torre J, Verdoy D, de Manuel Keenoy E, Fullaondo A.   +49 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Implementation Process of Project Control Systems and Performance of Rural Roads Construction Projects in Kenya: Role of Project Team Experience Diversity

, 2016
J. O. Obare, D. Kyalo, A. Mulwa, J. Mbugua   +3 more
semanticscholar   +1 more source

Acceptability and functional benefits of a health promotion program in pediatric oncology: a mixed-methods study. [PDF]

Front Pediatr
Demers C, Higgins J, Kerba J, Bouchard I, Meloche C, Curnier D, Marcil V, Sultan S, Laverdière C, Sinnett D, Gélinas I.   +10 more
europepmc   +1 more source

Correction: A multicenter cross-sectional survey on the status and influencing factors of health communication competence among primary healthcare workers. [PDF]

Front Public Health
Zhao X, Zhao J, Shi Z, Li T, Zhao L, Li R, Li L.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Integration of Transcriptomics With Interpretable Artificial Intelligence for Identifying Molecular Signatures of Physiological Stress in Sleep Deprivation. [PDF]

J Cell Mol Med
Wang K, Zong Q, Wang C, Wang P, Shuai Z, Wu M, Peng Y, Zhou J, Shuai J, Ye F, Wu A, Zheng Y.   +11 more
europepmc   +1 more source

Morris K. Udall - Central Arizona Project

Salt River Project Task Force concludes that four plans to control Arizona's Water Control Problems are Acceptable. All would Modify Roosevelt Dam and Build a New Dam (Cliff Dam)
Salt River Project, Public Information Section
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source