Results 91 to 100 of about 354,602 (309)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Diaspora Humanitarianism: Findings of the Diaspora Emergency Action and Coordination Project
, 2016 This final Report and Handbook presents the data and findings of the Diaspora Emergency Action and Coordination (DEMAC) project. It includes operational recommendations for diaspora, donors and institutional actors to improve mutual coordination, based ...
Phillips, Melissa (R19498)
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Scientific ReportsSubtilisin-like serine proteases (SBTs) are serine proteolytic enzymes that play various roles in plant growth, function and stress responses. Vigna glabrescens, a wild relative of mungbean known to be a potential donor of photo- and thermoperiod ...
Poornima Singh +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
LES PRATIQUES DE COORDINATION EN ENVIRONNEMENT VOLATILE : LE CAS DES FORCES AERIENNES FRANÇAISES EN SITUATION OPERATIONNELLE [PDF]
L'objectif de cet article est d'analyser les pratiques de coordination en environnement volatile en examinant leur nature et leur contenu. Afin d'enrichir les perspectives du gestionnaire en termes de gestion de la coordination, nous cherchons à la fois ...
Cécile Godé-Sanchez
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Coordination in Software Agent Systems [PDF]
, 1996 The objective of this paper is to examine the crucial area of coordination in multi-agent systems. It does not attempt to provide a comprehensive overview of the coordination literature; rather, it highlights the necessity for coordination in agent ...
Nwana, H. S. +8 more
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Improving project manufacturing coordination
, 2014 The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system.
Kässi, T. +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Creating Collaborative Advantages Through Coordination of Regional Development Activities [PDF]
Through the increasing importance of networking and use of participatory strategic planning approaches in the regional development practice, it seems that local and regional development theory moves from the concept of competitive advantages towards ...
Marijana Sumpor
core