Results 61 to 70 of about 354,602 (309)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The impact of project management skills, IT integration, supply chain coordination, process innovation, and communication language on organizational performance in educational institutions [PDF]

Journal of Project Management
This study investigates the impact of project management capabilities on organizational performance, with a particular focus on the mediating roles of supply coordination, information technology integration, and process innovation.
Mohammed Al Matalka, Mohammad Alzoubi, Wadha Al Zouair, Mohamed Kamel AlDowaikat, Shadi Said Alkhazaleh, Ahmad Ibrahim Khalid Matalqeh   +5 more
doaj   +1 more source

eHealth for patients with rare diseases: the eHealth Working Group of the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN)

Orphanet Journal of Rare Diseases, 2021
Background The European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN) was launched in 2017 and involves, to date, 35 highly specialised multidisciplinary expert centres (from the 30 full Healthcare Provider members) coming from 11 ...
Alessia Paglialonga, Raffaella Gaetano, Leema Robert, Marine Hurard, Luisa Maria Botella, Natasha Barr, Guillaume Jondeau, Alessandro Pini   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Effects of nickel sulphate and lead acetate trihydrate on heavy metal stress-related gene activities in forage pea (Pisum sativum ssp. arvense L.) in Türkiye

Frontiers in Plant Science
Researching heavy metal stress in plants is of paramount importance due to the increasing prevalence of heavy metal contamination in the environment, which poses significant risks to both plant, animal, and human health.
Seda Mesci, Muhammed İkbal Çatal
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Addressing the UHC Challenge Using the Disease Control Priorities 3 Approach: Lessons Learned and an Overview of the Pakistan Experience [PDF]

International Journal of Health Policy and Management
Background  Pakistan developed its first national essential package of health services (EPHS) as a key step towards accelerating progress in achieving universal health coverage (UHC).
Ala Alwan, Sameen Siddiqi, Malik Safi, Raza Zaidi, Muhammad Khalid, Rob Baltussen, Ina Gudumac, Maryam Huda, Maarten Jansen, Wajeeha Raza, Sergio Torres-Rueda, Wahaj Zulfiqar, Anna Vassall   +12 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Communications network centrality correlates to organisational coordination

, 2009
We explore the correlation between actor centrality and project-based coordination. By drawing from established coordination and organisational process theory, a text-mining tool is designed and implemented to measure coordination from a large dataset on
Wu, A, Hossain, L
core   +1 more source