Results 121 to 130 of about 114,951 (282)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

SCIENTIFIC-TECHNOLOGICAL PROGRESS OF UZBEKISTAN: PROBLEMS AND PROSPECTS

The article considers aspects concerning effective coordination of scientific-technological development in Uzbekistan. In the conditions of new economy, insufficient development and use of innovations in the domestic economy will contain the rate of ...
Azimov, Abror
core  

Chinese Adaptation and Application of the Design Governance Toolkit in the Context of Urban Regeneration

Fengjing Yuanlin
ObjectiveAs China’s urbanization transitions from rapid expansion to steady development, urban regeneration has entered a complex governance stage characterized by diversified stakeholder interests and an urgent need to safeguard the public interest ...
Shifu WANG, Haiyan LONG, Xiaoqi LIANG
doaj   +1 more source

Resolving the Cu(bdc) Conundrum: Identifying Non‐Porous Packing of Prototypical Coordination‐Network Thin Films Combining Advanced Diffraction Techniques and Computational Modelling

Advanced Functional Materials, EarlyView.
Solution‐processed Cu(bdc) forms prototypical MOF thin films for which a multitude of not fully satisfactory structural models have been suggested. Combining rotating grazing‐incidence diffraction and X‐ray reflectivity on two complementary samples with density‐functional theory, we first discard the previously suggested models and then identify a non ...
Narges Taghizade, Mario Fratschko, Robbin Steentjes, Mercedes Linares‐Moreau, Paolo Falcaro, Christof Wöll, Roland Resel, Egbert Zojer   +7 more
wiley   +1 more source

Navigating Norman Creek Online Digital Media

, 2016
This is interactive Digital Media in association with the Norman Creek Catchment Coordination committee that is ancillary to the main Navigating Norman Creek exhibition. Research Background (including field, context and research question) Witcomb (2010)
Veitch, Angus, FitzSimons, Patricia
core  

Solutions for Kids in Pain: Embedding and actioning patient partnership in a national knowledge mobilization network

Research Involvement and Engagement
Background Patient engagement is now often expected or required by funders for research projects, initiatives, or networks. Solutions for Kids in Pain (SKIP) is a national knowledge mobilization network in Canada that is on a mission to mobilize evidence-
Dawn P. Richards, Christine T. Chambers, Isabel Jordan, Kimberly Strain, Raad Fadaak, Louise Tunnah, Emily Gruenwoldt, Kathryn A. Birnie   +7 more
doaj   +1 more source

ENIGMA-shock: protocol for a study framEwork for aN InteGrated assessMent of cArdiac rehabilitation programmes in patients acutely managed for cardiogenic shock

BMJ Open
Introduction The treatment of patients with cardiogenic shock (CS) has been focused historically on single interventions (medical treatments, percutaneous and surgical interventions and, more recently, various temporary mechanical circulatory supports ...
Daniela Aschieri, Guido Tavazzi, Nuccia Morici, Fabrizio Oliva, Simone Frea, Paolo Pedersini, Emanuela Foglia, Lucreazia Ferrario, Marco Corda, Amelia Ravera, Letizia M Oreni, Ignazio Cusmano, Laura Garatti, Anastasia Toccafondi, Alice Sacco, Andrea Garascia, Massimo Pistono, Federico Pappalardo   +17 more
doaj   +1 more source

Automatic assembly design project 1968/9: report of assembly analysis and coordination committee

, 1969
The present assembly method and component parts of a chosen product are analysed. The design of components is investigated, and a workstation sequence is proposed based upon the modified components. A pick-and-place head is designed, versatility being the main design criterion. A functional check mechanism is designed.
openaire   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source