Results 41 to 50 of about 139,293 (301)
The management of project management: a conceptual framework for project governance
, 2014 For an organization to create optimal value from its investment in projects there must be a clear link between the outputs created by the projects and the requirements of the organization's business strategy.
Too, Eric G., Weaver, Patrick
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Alternative Approaches to Innovation Project Portfolio Governance [PDF]
The governance of projects is often treated operationally, as project portfolio management. Project portfolio governance is more strategic and continuous than project portfolio management, but its various approaches are weakly understood.
Martinsuo Miia, Tuominen Siiri
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Indigenous governance bibliography [PDF]
, 2015 AIATSIS has compiled this bibliography on Indigenous governance as part of its Indigenous Governance Building: Mapping current and future research and practical resource needs project. It is to be read in conjunction with an AIATSIS bibliography on free,
Lara Wiseman +2 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Governance challenges in temporary organizations: a case of evolution and representations
International Journal of Information Systems and Project Management, 2022 According to the literature, formal project governance often stops at the steering committee, which is also identified as the main link between the permanent and temporary organizations.
Magali Simard, Danielle Laberge
doaj +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Front-End Project Governance: Choice of Project Concept and Decision-Making– An International Perspective [PDF]
, 2013 The demand for new investment projects is increasing; however, the preparation of a large number of those projects has had practical problems and the relevant systems and processes have been criticized. According to recent publications, a lack of problem
Shiferaw, Asmamaw Tadege
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Systems Engineering in Front-End Governance of Major Public Investment Projects
Systems, 2017 This paper provides an account of how systems engineering principles are applied by the Norwegian government to improve up-front planning and decision-making of large public investment projects, as well as the effect of these efforts after 15 years of ...
Knut Samset
doaj +1 more source