Results 71 to 80 of about 139,293 (301)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

State, Society and Governance in Melanesia Project: review 1995-1998

, 1998
The State, Society and Governance in Melanesia Project is an outstanding example of collaboration between university and government sectors. The Project was conceived in December 1994 when Pacific Islands specialists in the Research School of Pacific and
Dinnen, Sinclair, Douglas, Bronwen, Regan, Anthony   +2 more
core   +1 more source

Enhancing IT Project Sustainability: The Role of Collaborative Resources, Stakeholder Engagement, and Project Governance

Business Review
The purpose of this research is to examine the impact of collaborative social resources on project sustainability in Pakistan's IT Projects, with particular emphasis on the mediating effect of stakeholder engagement and the moderating role of project ...
Laiba Tahir, Arif Uddin
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Investigating the Challenges of Project Governance Processes of IT Projects

Procedia Computer Science, 2018
Abstract This study investigates challenges of project governance processes of Information Technology (IT) projects in organisations. There is still a high prevalent failure rate in implementation of IT projects or initiatives. The failure can be attributed to various factors, which one of the factors could be the existence of Project Governance ...
Refiloe E. Mashiloane, Osden Jokonya
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Practical Project Governance Approaches to Achieving Inter-Organization Collaboration Between Stakeholders in Off-Site Construction Projects: Adaptive Dynamic Perspective

Buildings
As an essential domain of project management, inter-organization collaboration (IOC) is crucial for stakeholders in off-site construction (OSC) projects because of the high linkage between design, production, and site construction stages. Current studies
Xiaoyan Xue, Hong Xue
doaj   +1 more source

Enterprise resource planning systems implementation as a complex project: A conceptual framework

Journal of Business Economics and Management, 2010
The purpose of this paper is to investigate current literature on critical success factors (CSF) and risk factors (RF) of enterprise resource planning (ERP) system implementation and provide a systemic explanation of complexities involved in such ...
Saumyendu Ghosh, Mirosław J. Skibniewski   +1 more
doaj   +1 more source

DEFINING 'PROJECT GOVERNANCE' FOR LARGE CAPITAL PROJECTS

The South African Journal of Industrial Engineering, 2009
Over the past decade corporate governance has received ample attention. Lately the principles of governance have been applied to other management disciplines, especially project management. The evolution of the concept of 'project governance' resulted in various interpretations and applications of the term, causing confusion among academics and ...
Bekker, M.C. (Michiel Christiaan), Steyn, Herman   +1 more
openaire   +3 more sources