Results 91 to 100 of about 139,293 (301)

Readiness-Gate Governance in Public Infrastructure Projects Preventing Premature Milestones, Infrastructure Gridlocks and Trust Loss

Journal of Asia Entrepreneurship and Sustainability
Public infrastructure projects often lose time and trust not simply because engineering work is difficult, but because leaders commit to milestones before the conditions required for those milestones are mature.
Dr. Alok Kumar Bhargava, Dr. Sonali Sneha   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Acceptability Scale for the Use of Large Language Models (LLMs) by Project Teams: Development and Preliminary Validation

Systems
The use of Large Language Models (LLMs) in organizational contexts has grown rapidly, particularly in project management activities. Despite this expansion, a relevant methodological gap can be observed in the literature: the absence of psychometrically ...
Murilo Zanini de Carvalho, Renato Penha, Leonardo Vils, Flávio Santino Bizarrias, Fernando Antonio Ribeiro Serra   +4 more
doaj   +1 more source

Governance, governmentality and project performance: the role of sovereignty

International Journal of Information Systems and Project Management, 2019
Considerable confusion prevails in the mutual positioning and relationship of concepts like management, leadership, governance and governmentality in projects.
Ralf Müller, , , ,
doaj   +1 more source

Governing and (re)producing project governance [PDF]

, 2019
Public-Private Partnerships (PPPs) are usually presented as collaborative inter-organizational relationships between public and private organizations for increasing the efficiency of public infrastructure delivery. Yet, PPPs are realized in very particular long-term contractual engagements, whose effects on the quality of the partnership and its ...
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Ocean governance: the New Zealand dimension [PDF]

, 2012
  The Oceans Governance project was funded by the Emerging Issues Programme, overseen by the Institute of Policy Studies at Victoria University of Wellington. Its primary goal is to provide interested members of the public and policymakers with a
Michael Vincent McGinnis
core  

Minimizing Cost Overrun in Rail Projects Through 5D-Bim: The Case Study of Victoria

Infrastructures
This study evaluates the adoption and efficacy of the 5th Dimension Building Information Modelling (5D-BIM) as a cost dimension for mega rail projects, extending the discussion beyond just technological implementation to consider broader policy and ...
Osama A. I. Hussain, Robert C. Moehler, Stuart D. C. Walsh, Dominic D. Ahiaga-Dagbui   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

When capital meets control: governance dilemmas of financial investors in PPP projects

Journal of Civil Engineering and Management
While financial investors typically provide substantial share of capital in Public Private Partnership (PPP) Projects, they frequently lack meaningful operational control, leaving them vulnerable to opportunism from both government entities and ...
Chuan Chen, Baoheng Chen
doaj   +1 more source