Results 91 to 100 of about 9,735,717 (300)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The importance of project governance framework in project procurement planning [PDF]

, 2011
Project Procurement is a ‘great’ environment for ethical issues with its low-price state of mind and competition. It has many opportunities that could contribute to illegal activities or unethical behavior especially in the construction industry. In 2006
Trigunarsyah Bambang, Abu Hassim, Aliza, Trigunarsyah, Bambang, Abu Hassim Aliza, Kajewski Stephen, Kajewski, Stephen L.   +5 more
core   +1 more source

Enterprise resource planning systems implementation as a complex project: A conceptual framework

Journal of Business Economics and Management, 2010
The purpose of this paper is to investigate current literature on critical success factors (CSF) and risk factors (RF) of enterprise resource planning (ERP) system implementation and provide a systemic explanation of complexities involved in such ...
Saumyendu Ghosh, Mirosław J. Skibniewski   +1 more
doaj   +1 more source

DEFINING 'PROJECT GOVERNANCE' FOR LARGE CAPITAL PROJECTS

The South African Journal of Industrial Engineering, 2009
Over the past decade corporate governance has received ample attention. Lately the principles of governance have been applied to other management disciplines, especially project management. The evolution of the concept of 'project governance' resulted in various interpretations and applications of the term, causing confusion among academics and ...
Bekker, M.C. (Michiel Christiaan), Steyn, Herman   +1 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

State, Society and Governance in Melanesia Project: review 1995-1998

, 1998
The State, Society and Governance in Melanesia Project is an outstanding example of collaboration between university and government sectors. The Project was conceived in December 1994 when Pacific Islands specialists in the Research School of Pacific and
Dinnen, Sinclair, Douglas, Bronwen, Regan, Anthony   +2 more
core   +1 more source

Massive Institutional Structures in Global Governance [PDF]

, 2021
Global governance consists of elementary regimes that form regime complexes, which in turn give rise to what we call superclusters around broad policy domains.
Kim, Rakhyun E., Morin, Jean-Frédéric, Environmental Governance   +2 more
core  

How does contractual governance affect construction project performance? The mediating role of the contractor’s behavior

Journal of Asian Architecture and Building Engineering
The contractor’s performance behavior is fundamental in improving project performance. However, few studies have investigated the impact of contractual mechanisms on contractor’s performance behavior and how this impacts project performance.
Yazhuo Luo, Yuanze Chen
doaj   +1 more source

Practical Project Governance Approaches to Achieving Inter-Organization Collaboration Between Stakeholders in Off-Site Construction Projects: Adaptive Dynamic Perspective

Buildings
As an essential domain of project management, inter-organization collaboration (IOC) is crucial for stakeholders in off-site construction (OSC) projects because of the high linkage between design, production, and site construction stages. Current studies
Xiaoyan Xue, Hong Xue
doaj   +1 more source