Results 101 to 110 of about 9,735,717 (300)

Deficiencies in Project Governance: An Analysis of Infrastructure Development Program

Administrative Sciences, 2019
The governance of public sector infrastructure projects became an important topic of interest in the project, program, and portfolio management literature during the last decade.
Asadullah Khan, Muhammad Waris, Ishak Ismail, Mirza Rizwan Sajid, Mehfooz Ullah, Faisal Usman   +5 more
doaj   +1 more source

Investigating the Challenges of Project Governance Processes of IT Projects

Procedia Computer Science, 2018
Abstract This study investigates challenges of project governance processes of Information Technology (IT) projects in organisations. There is still a high prevalent failure rate in implementation of IT projects or initiatives. The failure can be attributed to various factors, which one of the factors could be the existence of Project Governance ...
Refiloe E. Mashiloane, Osden Jokonya
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Acceptability Scale for the Use of Large Language Models (LLMs) by Project Teams: Development and Preliminary Validation

Systems
The use of Large Language Models (LLMs) in organizational contexts has grown rapidly, particularly in project management activities. Despite this expansion, a relevant methodological gap can be observed in the literature: the absence of psychometrically ...
Murilo Zanini de Carvalho, Renato Penha, Leonardo Vils, Flávio Santino Bizarrias, Fernando Antonio Ribeiro Serra   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

When capital meets control: governance dilemmas of financial investors in PPP projects

Journal of Civil Engineering and Management
While financial investors typically provide substantial share of capital in Public Private Partnership (PPP) Projects, they frequently lack meaningful operational control, leaving them vulnerable to opportunism from both government entities and ...
Chuan Chen, Baoheng Chen
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Infrastructure Project Governance: An Analysis Of Public Sector Project In Northern Pakistan [PDF]

, 2018
Infrastructure projects in developing countries have been criticized for cost overrun, delay, substandard construction works, ineffectiveness and low efficiency. In this regard, the project governance approach offers a structured mechanism
Hussain, Ammar, Ishak, Ismail, Khan, Asadullah, M., Waris, Ilyas, Muhammad   +4 more
core   +1 more source

Minimizing Cost Overrun in Rail Projects Through 5D-Bim: The Case Study of Victoria

Infrastructures
This study evaluates the adoption and efficacy of the 5th Dimension Building Information Modelling (5D-BIM) as a cost dimension for mega rail projects, extending the discussion beyond just technological implementation to consider broader policy and ...
Osama A. I. Hussain, Robert C. Moehler, Stuart D. C. Walsh, Dominic D. Ahiaga-Dagbui   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source