Results 121 to 130 of about 139,293 (301)

Assistance, buy-in, and champions: The ABCs of sustaining leadership and management interventions

Annals of Global Health, 2016
Reshma Trasi, Monica Rao Biradavolu, Anupa Deshpande   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Community - Based Water Monitoring : Build Your Own Water Monitoring Logger

, 2018
Water security for Indigenous communities is an urgent issue. Approximately one third of Indigenous communities in Canada are currently grappling with safe drinking water access, compromised environmental water quality, and associated health issues ...
Sustainable Water Governance and Indigenous Law Project
core  

Policy Brief on Institutional Barriers and Enablers. Blue Green Governance: Deliverable 1.2

This policy brief, with its structure along the five dimensions and the barriers and enablers therein, aims to enrich existing frameworks for analyzing coastal governance.
Đinh, Linh, Nijamdeen, Fathima Mafaziya, Kvanneid, Aase Jeanette, Johannesen, Ellen, Salès, Katherine, Fobé, Ellen, Douguet, Jean-Marc, Blatrix, Cécile, Platjouw, Froukje Maria, Trubbach, Saskia, Beunen, Raoul   +10 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Governance and returns on investment : an empirical investigation [PDF]

Using data from the World Bank's Operations Evaluation Department, the authors examine the link between the performance of Bank-financed projects and various indicators of country governance.
Isham, Jonathan, Pritchett, Lant, Kaufmann, Daniel   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Navigating toward Sustainable Development: Conceptual maps of modes of governance vs. practical experiences in the Dutch fen landscape

, 2014
In a rare comparative analysis of governance towards sustainable governance, this thesis investigates three modes most prominent in the literature, i.e. adaptive management, transition management and payments for environmental services.
den Uyl, Roos, Environmental Governance
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Institutional gatekeeping and change order prevention in public infrastructure projects: evidence from a governance reform in Jordan

Frontiers in Built Environment
This study examines change order behavior in public road infrastructure as a two-stage process separating occurrence from conditional severity. Using an official dataset of 157 projects in Jordan (116 pre-policy, 41 post-policy), the analysis applies ...
Mohammed A. K. A. Al-Btoush, Hashem Khaled Almashaqbeh, Taiseer Mustafa Rawashdeh, Jafar A. Aldiabat Al-Btoosh, Imad Al Shalout, Mahmoud Ali Alsubeh   +5 more
doaj   +1 more source